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Focused tandem shock waves in water and their potential application in cancer treatment

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389021%3A_____%2F11%3A00369995" target="_blank" >RIV/61389021:_____/11:00369995 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Focused tandem shock waves in water and their potential application in cancer treatment

  • Original language description

    Physical principles of novel type of generator of focused tandem shock waves with time delay between the first and second shock waves of 10 ?s have been presented. Generator produces at the focus strong shock wave with peak positive pressure up to 80 MPafollowed by tensile wave with peak negative pressure down up to -80 MPa, generating thus at the focus a large number of cavitation. Biological effects of FTSW were demonstrated in vitro on hemolysis of erythrocytes and cell viability of acute lymphoblastic leukemia cells, and on tumor growth delay experiments ex vivo and in vivo. Synergetic cytotoxicity of FTSW with Photosan on tumor growth was observed, possibly due to cavitation induced sonodynamic effect of FTSW.

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

    BL - Plasma physics and discharge through gases

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GA202%2F09%2F1151" target="_blank" >GA202/09/1151: Focused tandem shock waves and their potential application in cancer treatment and controlled drug delivery</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    Proceedings of 28th International Symposium on Shock Waves

  • ISBN

    978-3-642-25687-5

  • ISSN

  • e-ISSN

  • Number of pages

    6

  • Pages from-to

    "P"-"2849-P-2849"

  • Publisher name

    Springer Verlag

  • Place of publication

    Manchester

  • Event location

    Manchester

  • Event date

    Jul 17, 2011

  • Type of event by nationality

    WRD - Celosvětová akce

  • UT code for WoS article