Focused tandem shock waves in water and their potential application in cancer treatment

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10290555" target="_blank" >RIV/00216208:11110/14:10290555 - isvavai.cz</a>

Alternative codes found

RIV/61389021:_____/14:00423247

Result on the web

<a href="http://dx.doi.org/10.1007/s00193-013-0462-7" target="_blank" >http://dx.doi.org/10.1007/s00193-013-0462-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00193-013-0462-7" target="_blank" >10.1007/s00193-013-0462-7</a>

Result language

angličtina

Original language name

Focused tandem shock waves in water and their potential application in cancer treatment

Original language description

The generator of two focused successive (tandem) shock waves (FTSW) in water produced by underwater multichannel electrical discharges at two composite electrodes, with a time delay between the first and second shock waves of 10 mu s, was developed. It produces, at the focus, a strong shock wave with a peak positive pressure of up to 80 MPa, followed by a tensile wave with a peak negative pressure of up to -80 MPa, thus generating at the focus a large amount of cavitation. Biological effects of FTSW were demonstrated in vitro on hemolysis of erythrocytes and cell viability of human acute lymphoblastic leukemia cells as well as on tumor growth delay ex vivo and in vivo experiments performed with B16 melanoma, T-lymphoma, and R5-28 sarcoma cell lines. Itwas demonstrated in vivo that FTSW can enhance antitumor effects of chemotherapeutic drugs, such as cisplatin, most likely due to increased permeability of the membrane of cancer cells induced by FTSW. Synergetic cytotoxicity of FTSW wit

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

—

Project

<a href="/en/project/GA202%2F09%2F1151" target="_blank" >GA202/09/1151: Focused tandem shock waves and their potential application in cancer treatment and controlled drug delivery</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Shock Waves

ISSN

0938-1287

e-ISSN

—

Volume of the periodical

24

Issue of the periodical within the volume

1

Country of publishing house

DE - GERMANY

Number of pages

7

Pages from-to

51-57

UT code for WoS article

000331656400007

EID of the result in the Scopus database

—