Antiapoptotic and Proapoptotic Action of Various Amino Acids and Analogs in Starving MOLT-4 Cells.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F02%3A56023002" target="_blank" >RIV/61389030:_____/02:56023002 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Antiapoptotic and Proapoptotic Action of Various Amino Acids and Analogs in Starving MOLT-4 Cells.
Original language description
This study is based on our previous findings showing that certain amino acids may protect hybridoma cells against starvation-induced apoptosis. In the present work we have screened 44 amino acids and analogs for their capacity of modulating apoptosis inhuman T-lymphoblastic leukemia cell line MOLT-4 exposed to starvation in a nutrient-poor medium. The panel of tested substances was found to contain not only compounds with antiapoptotic activity (e.g., L-glutamine, L-histidine, glycine, L-proline, and L-2-aminopentanoic acid), but also compounds with proapoptotic activity (e.g., L-phenylalanine, L-tryptophan, L-arginine, and L-2-aminohexanoic acid). The apoptosis-modulating effects were dependent on fine details of the structure of the compounds. A switch from antiapoptotic activity to proapoptotic activity was found between 6-ami-nohexanoic acid and 7-aminoheptanoic acid, as well as between L-2-aminopentanoic acid and L-2-aminohex-anoic acid. D-amino acids tested were without effect.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/OC%20844.10" target="_blank" >OC 844.10: Modulation of apoptosis in cell systems by signal molecules of natural and synthetic origin</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2002
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Archives of Biochemistry and Biophysics
ISSN
0003-9861
e-ISSN
—
Volume of the periodical
398
Issue of the periodical within the volume
1
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
6
Pages from-to
141-146
UT code for WoS article
—
EID of the result in the Scopus database
—