All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

6-benzylamino-2-(2-hydroxyethylamino)-9-methylpurine-1,7-diium bis(perchlorate) monohydrate

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F04%3A00109760" target="_blank" >RIV/61389030:_____/04:00109760 - isvavai.cz</a>

  • Alternative codes found

    RIV/61989592:15310/04:00009885

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    6-benzylamino-2-(2-hydroxyethylamino)-9-methylpurine-1,7-diium bis(perchlorate) monohydrate

  • Original language description

    The title compound, C15H20N6O2+ . 2ClO(4)(-).H2O, belongs to a group of cytokinin-derived compounds. It has been found that some cytokinin derivatives, e. g. 2,6,9-trisubstituted purine derivatives, behave as potent inhibitors of cyclin-dependent kinases(CDKs) and show anticancer activity. Olomoucine, i.e. the title cation in its neutral form, represents one of the first CDK specific inhibitors that selectively blocks CDK1, CDK2 and CDK5 kinases at micromolar concentrations. The asymmetric unit of thetitle compound consists of the diprotonated cation, two perchlorate anions and a water molecule of crystallization. The cation contains nearly planar benzene and purine ring systems, the dihedral angle between them being 46.77 (6) degrees. The crystal structure is stabilized by N-purine - H ... O-water/O-hydroxy, N-amine - H ... O-water/O-hydroxy, O-water - H ... O-perchlorate and O-hydroxy - H ... O-perchlorate hydrogen bonds.

  • Czech name

    6-benzylamino-2-(2-hydroxyethylamino)-9-methylpurine-1,7-diium bis(perchlorate) monohydrate

  • Czech description

    6-benzylamino-2-(2-hydroxyethylamino)-9-methylpurine-1,7-diium bis(perchlorate) monohydrate.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GP204%2F03%2FD231" target="_blank" >GP204/03/D231: Biological activity of new inhibitors of cyclin-dependent kinases</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2004

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE

  • ISSN

    1600-5368

  • e-ISSN

  • Volume of the periodical

    60

  • Issue of the periodical within the volume

    12

  • Country of publishing house

    DK - DENMARK

  • Number of pages

    4

  • Pages from-to

    "o2324"-"o2327"

  • UT code for WoS article

  • EID of the result in the Scopus database