6-benzylamino-2-(2-hydroxyethylamino)-9-methylpurine-1,7-diium bis(perchlorate) monohydrate
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F04%3A00002290" target="_blank" >RIV/61989592:15310/04:00002290 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
6-benzylamino-2-(2-hydroxyethylamino)-9-methylpurine-1,7-diium bis(perchlorate) monohydrate
Original language description
The title compound, C15H20N6O2+.2ClO(4)(-).H2O, belongs to a group of cytokinin-derived compounds. It has been found that some cytokinin derivates, e. g. 2,6,9-trisubstituted purine derivates, behave as potent inhibitors of cyclin-dependent kinases (CDKs) and show anticancer activity. Olomoucine, i. e. the title cation in its neutral form, represents one of the first CDK specific inhibitors that selectively blocks CDK1, CDK2 and CDK5 kinases at micromolar concentrations. The asymmetric unit of the titlecompound consists of the diprotonated cation, two perchlorate anions and a water molecule of crystallization. The cation contains nearly planar benzene and purine ring systems, the dihedral angle between them being 46.77(6) degrees. The crystal strucureis stabilized by N-purine - H ... O-water/O-hydroxy, N-amine - H ... O-water/O-hydroxy, O-water - H ... O-perchlorate and O-hydroxy - H ... O-perchlorate hydrogen bonds.
Czech name
Chloristan 6-benzylamino-2-(2-hydroxyethylamino)-9-methylpurin-1,7-diia monohydrát
Czech description
Byl studován chloristan 6-benzylamino-2-(2-hydroxyethylamino)-9-methylpurin-1,7-diia monohydrát.
Classification
Type
A - Audiovisual production
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
ISBN
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Place of publication
Neuveden
Publisher/client name
Blackwell Munksgaard
Version
60
Carrier ID
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