In Vitro and In Vivo Comparison of Selected Ga-68 and Zr-89 Labelled Siderophores

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F16%3A00461642" target="_blank" >RIV/61389030:_____/16:00461642 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/16:33160791
Result on the web
<a href="http://dx.doi.org/10.1007/s11307-015-0897-6" target="_blank" >http://dx.doi.org/10.1007/s11307-015-0897-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11307-015-0897-6" target="_blank" >10.1007/s11307-015-0897-6</a>

Result language
angličtina
Original language name
In Vitro and In Vivo Comparison of Selected Ga-68 and Zr-89 Labelled Siderophores
Original language description
Some [Ga-68]siderophores show promise in specific and sensitive imaging of infection. Here, we compare the in vitro and in vivo behaviour of selected Ga-68 and Zr-89 labelled siderophores. nnRadiolabelling was performed in HEPES or sodium acetate buffer systems. Radiochemical purity of labelled siderophores was determined using chromatography. Partition coefficients, in vitro stability and protein binding affinities were determined. Ex vivo biodistribution and animal imaging was studied in mice. nnCertain differences among studied siderophores were observed in labelling efficiency. Protein binding and stability tests showed highest stabilities and lowest protein binding affinities for Ga-68 and [Zr-89]triacetylfusarinine C (TAFC). All studied Ga-68 and [Zr-89]siderophores exhibited a similar biodistribution and pharmacokinetics in mice with the exception of [Zr-89]ferrioxamine E (FOXE). nnZr-89 and [Ga-68]siderophores showed analogous in vitro and in vivo behaviour. Tested [Zr-89]siderophores could be applied for longitudinal positron emission tomography (PET) studies of fungal infections and especially TAFC for the development of novel bioconjugates.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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