Preclinical evaluation of two 68Ga-siderophores as potential radiopharmaceuticals for Aspergillus fumigatus infection imaging

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33140502" target="_blank" >RIV/61989592:15110/12:33140502 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s00259-012-2110-3" target="_blank" >http://dx.doi.org/10.1007/s00259-012-2110-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00259-012-2110-3" target="_blank" >10.1007/s00259-012-2110-3</a>

Result language

angličtina

Original language name

Preclinical evaluation of two 68Ga-siderophores as potential radiopharmaceuticals for Aspergillus fumigatus infection imaging

Original language description

Purpose Invasive pulmonary aspergillosis is mainly caused by Aspergillus fumigatus, and is one of the major causes of morbidity and mortality in immunocompromised patients. The mortality associated with invasive pulmonary aspergillosis remains high, mainly due to the difficulties and limitations in diagnosis. We have shown that siderophores can be labelled with Ga-68 and can be used for PET imaging of A. fumigatus infection in rats. Here we report on the further evaluation of the most promising Ga-68-siderophore candidates, triacetylfusarinine (TAFC) and ferrioxamine E (FOXE). Methods Siderophores were labelled with Ga-68 using acetate buffer. Log P, protein binding and stability values were determined. Uptake by A. fumigatus was studied in vitro in cultures with high and low iron loads. In vivo biodistribution was determined in normal mice and an infection model was established using neutropenic rats inoculated with A. fumigatus. Static and dynamic mu PET imaging was performed and cor

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/ED0030%2F01%2F01" target="_blank" >ED0030/01/01: Biomedicine for regional development and human resources</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Nuclear Medicine and Molecular Imaging

ISSN

1619-7070

e-ISSN

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Volume of the periodical

39

Issue of the periodical within the volume

7

Country of publishing house

DE - GERMANY

Number of pages

9

Pages from-to

1175-1183

UT code for WoS article

000305215500012

EID of the result in the Scopus database

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