Siderophores: a potential role as a diagnostic for invasive fungal disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F22%3A00564787" target="_blank" >RIV/61388971:_____/22:00564787 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/22:73615597
Result on the web
<a href="https://journals.lww.com/co-infectiousdiseases/Abstract/2022/12000/Siderophores__a_potential_role_as_a_diagnostic_for.2.aspx" target="_blank" >https://journals.lww.com/co-infectiousdiseases/Abstract/2022/12000/Siderophores__a_potential_role_as_a_diagnostic_for.2.aspx</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/QCO.0000000000000862" target="_blank" >10.1097/QCO.0000000000000862</a>
Alternative languages
Result language
angličtina
Original language name
Siderophores: a potential role as a diagnostic for invasive fungal disease
Original language description
Purpose of reviewInvasive fungal diseases (IFDs) such as invasive aspergillosis continue to be associated with high morbidity and mortality while presenting significant diagnostic challenges. Siderophores are high-affinity Fe3+ chelators produced by Aspergillus spp. and other fungi capable of causing IFD. Previously evaluated as a treatment target in mucormycosis, siderophores have recently emerged as new diagnostic targets for invasive aspergillosis and scedosporiosis. Here, we review the diagnostic potential of siderophores for diagnosing IFD, with a particular focus on invasive aspergillosis.Recent findingsThe major secreted siderophore of A. fumigatus, triacetylfusarinine C (TAFC), has been successfully detected by mass spectrometry in serum, BALF and urine of patients with invasive aspergillosis, with promising sensitivities and specificities in single-centre studies. Intracellular uptake of siderophores has also been utilized for imaging, wherein fungal siderophores have been conjugated with the easy-to-produce radioactive isotope gallium-68 (Ga-68) to visualize infected body sites in PET. For the Scedosporium apiospermum complex, another siderophore N(alpha)-methyl coprogen B has been shown promising as a marker for airway colonization in early studies.Siderophores and particular TAFC have the potential to revolutionize diagnostic pathways for invasive aspergillosis and other mould infections. However, larger multicentre studies are needed to confirm these promising performances. Methods that allow rapid and cost-effective measurements in routine clinical practice need to be developed, particularly when TAFC is used as a biomarker in patient specimens.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
<a href="/en/project/GA21-17044S" target="_blank" >GA21-17044S: Next-generation infection diagnostics</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Opinion in Infectious Diseases
ISSN
0951-7375
e-ISSN
1473-6527
Volume of the periodical
35
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
485-492
UT code for WoS article
000883119300001
EID of the result in the Scopus database
2-s2.0-85141893280