Novel fluorinated benzimidazole-based scaffolds and their anticancer activity in vitro
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F16%3A00463793" target="_blank" >RIV/61389030:_____/16:00463793 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/16:33161109
Result on the web
<a href="http://dx.doi.org/10.1016/j.jfluchem.2016.06.009" target="_blank" >http://dx.doi.org/10.1016/j.jfluchem.2016.06.009</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jfluchem.2016.06.009" target="_blank" >10.1016/j.jfluchem.2016.06.009</a>
Alternative languages
Result language
angličtina
Original language name
Novel fluorinated benzimidazole-based scaffolds and their anticancer activity in vitro
Original language description
A small library of twelve, structurally diverse, fluoroaryl benzimidazoles was prepared using a simple synthetic strategy employing-SNAr reactions. This allowed rapid assembly of heterocyclic structures containing linked and tethered fluoroaryl benzimidazoles. X-ray crystal structures of seven compounds were obtained including those of two macrocyclic compounds containing 21- and 24-membered rings. Three tethered fluoroaryl benzimidazole derivatives demonstrated micromolar inhibition against K-562 and MCF-7 cell lines. These compounds, in addition to 1-tetrafluoropyrid-4-yl-2-tetrafluoropyrid-4ylsulfanyl-1H-benzimidazole, also demonstrated micromolar inhibition against G361 and HOS cell lines. Two of the compounds were found to activate caspases leading to apoptosis.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA15-15264S" target="_blank" >GA15-15264S: Targeted Transport of Purine Cyclin-dependent Kinase Inhibitors into Cancer Cells</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Fluorine Chemistry
ISSN
0022-1139
e-ISSN
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Volume of the periodical
188
Issue of the periodical within the volume
AUG
Country of publishing house
CH - SWITZERLAND
Number of pages
11
Pages from-to
99-109
UT code for WoS article
000381836000016
EID of the result in the Scopus database
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