In vitro antiinflammatory and antioxidant potential of root extracts from Ranunculaceae species
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F17%3A00476506" target="_blank" >RIV/61389030:_____/17:00476506 - isvavai.cz</a>
Alternative codes found
RIV/60460709:41210/17:71600 RIV/60460709:41340/17:71600
Result on the web
<a href="http://dx.doi.org/10.1016/j.sajb.2016.12.008" target="_blank" >http://dx.doi.org/10.1016/j.sajb.2016.12.008</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.sajb.2016.12.008" target="_blank" >10.1016/j.sajb.2016.12.008</a>
Alternative languages
Result language
angličtina
Original language name
In vitro antiinflammatory and antioxidant potential of root extracts from Ranunculaceae species
Original language description
Among the ethanol extracts of roots of 25 Ranunculaceous plant species traditionally used in treatment of various inflammatory diseases, Helleborus purpurascens demonstrated the most promising inhibitory activity towards COX-1, COX-2 and 5-LOX enzymes (IC 50 detected as 5.64, 10.33 and 3.84 μg/mL, respectively). GC–MS analysis of subfractions obtained from H. purpurascens extract revealed that a complex of fatty acids (especially α-linolenic acid) might be responsible for the observed antiinflammatory activity. The extract of Thalictrum minus was found to be selectively inhibiting COX-2 and 5-LOX enzymes (IC 50 = 49.68 and 76.47 μg/mL, respectively) but had no inhibitory effect on COX-1 (IC 50 > 128 μg/mL). Moreover, T. minus extract also showed significant antioxidant effect (DPPH = 0.074 g TE/g, and ORAC = 0.518 g TE/g) as well as was relatively rich on phenolic compounds (TPC = 0.352 g GAE/g). Statistical analysis showed that phenolic compounds might be only partially responsible for antioxidant potential demonstrated by this plant. The results of our study suggest that the above-mentioned members of Ranunculaceae family may possibly serve as a prospective material for further development of novel and safer plant-based antiinflammatory and/or antioxidant agents.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10611 - Plant sciences, botany
Result continuities
Project
<a href="/en/project/GA16-07193S" target="_blank" >GA16-07193S: Anti-inflammatory activity of selected stilbenoids, 2-arylbenzofuranes and their metabolites</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
South African Journal of Botany
ISSN
0254-6299
e-ISSN
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Volume of the periodical
109
Issue of the periodical within the volume
MAR
Country of publishing house
ZA - SOUTH AFRICA
Number of pages
10
Pages from-to
128-137
UT code for WoS article
000400465400016
EID of the result in the Scopus database
2-s2.0-85009121766