Transcriptomic response of Arabidopsis thaliana (L.) Heynh. roots to ibuprofen
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F17%3A00476651" target="_blank" >RIV/61389030:_____/17:00476651 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/17:10361544
Result on the web
<a href="http://dx.doi.org/10.1080/15226514.2016.1267697" target="_blank" >http://dx.doi.org/10.1080/15226514.2016.1267697</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/15226514.2016.1267697" target="_blank" >10.1080/15226514.2016.1267697</a>
Alternative languages
Result language
angličtina
Original language name
Transcriptomic response of Arabidopsis thaliana (L.) Heynh. roots to ibuprofen
Original language description
Surface waters in urban areas are contaminated by ibuprofen (IBP), a popular and extensively used anti-inflammatory drug. In this study, we investigated the transcriptomic response in Arabidopsis thaliana (L.) Heynh. roots with the aim of revealing genes that are potentially involved in IBP detoxification and elucidating the effect of IBP on plants. IBP upregulated 63 and downregulated 38 transcripts (p-value < 0.1, fold change ≥2) after 2-day exposure to a 5-µM (1.03 mg/L) concentration of IBP under hydroponic conditions. Although the IBP concentration used in the experiment was highly relative to the concentrations found in rivers and wastewater, the number of genes with transcriptional changes was relatively low. The upregulation of cytochrome P450s, glutathione S-transferases, and UDP-glycosyltransferases indicates the occurrence of IBP oxidation in the first phase, followed by conjugation with glutathione and sugar in the second detoxification phase. ABC transporters could be involved in the transport of IBP and its metabolites. The identification of genes potentially involved in IBP detoxification could be useful in an IBP phytoremediation approach.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10611 - Plant sciences, botany
Result continuities
Project
<a href="/en/project/GA14-22593S" target="_blank" >GA14-22593S: Metabolism of selected non-steroidal anti-inflammatory drugs in plants and its environmental consequences</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Phytoremediation
ISSN
1522-6514
e-ISSN
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Volume of the periodical
19
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
695-700
UT code for WoS article
000402041800001
EID of the result in the Scopus database
2-s2.0-85019615193