Biological activities of extract from Coleonema album in vitro

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F19%3A00510007" target="_blank" >RIV/61389030:_____/19:00510007 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.sajb.2019.06.015" target="_blank" >http://dx.doi.org/10.1016/j.sajb.2019.06.015</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.sajb.2019.06.015" target="_blank" >10.1016/j.sajb.2019.06.015</a>

Result language
angličtina
Original language name
Biological activities of extract from Coleonema album in vitro
Original language description
Coleonema album is a South African shrub which is used as an anti-inflammatory. A methanolic leaf extract of C. album was here tested in vitro in various anti-inflammatory assays to establish a possible mode of action, as well as for cytotoxicity. The C. album extract did not change the signaling of anti-inflammatory activity in vitro. The extract inhibited COX-1, COX-2 and IL-6, but not ELAM or ICAM-1. Pellitorine, an alkamide isolated and identified from C. album, did not show any activity in the anti-inflammatory assays. The extract showed no cytotoxicity in normal and cancer cell lines. Finally, pellitorine was identified in C. album by UHPLC-QTOF-MS and its concentration was determined by an external standard method.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10611 - Plant sciences, botany

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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