Biological activities of extract from Coleonema album in vitr
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F19%3A73598562" target="_blank" >RIV/61989592:15310/19:73598562 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0254629919305629" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0254629919305629</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.sajb.2019.06.015" target="_blank" >10.1016/j.sajb.2019.06.015</a>
Alternative languages
Result language
angličtina
Original language name
Biological activities of extract from Coleonema album in vitr
Original language description
Coleonema album is a South African shrub which is used as an anti-inflammatory. A methanolic leaf extract of C. album was here tested in vitro in various anti-inflammatory assays to establish a possible mode of action, as well as for cytotoxicity. The C. album extract did not change the signaling of anti-inflammatory activity in vitro. The extract inhibited COX-1, COX-2 and IL-6, but not ELAM or ICAM-1. Pellitorine, an alkamide isolated and identified from C. album, did not show any activity in the anti-inflammatory assays. The extract showed no cytotoxicity in normal and cancer cell lines. Finally, pellitorine was identified in C. album by UHPLC-QTOF-MS and its concentration was determined by an external standard method.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10611 - Plant sciences, botany
Result continuities
Project
<a href="/en/project/EF17_048%2F0007323" target="_blank" >EF17_048/0007323: Development of pre-applied research in nanotechnogy and biotechnology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
SOUTH AFRICAN JOURNAL OF BOTANY
ISSN
0254-6299
e-ISSN
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Volume of the periodical
126
Issue of the periodical within the volume
NOV
Country of publishing house
ZA - SOUTH AFRICA
Number of pages
6
Pages from-to
176-181
UT code for WoS article
000489157200020
EID of the result in the Scopus database
2-s2.0-85068470824