Anti-cancer activities of cytokinin ribosides

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F19%3A00512141" target="_blank" >RIV/61389030:_____/19:00512141 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/19:73598612 RIV/61989592:15310/19:73598612

Result on the web

<a href="http://dx.doi.org/10.1007/s11101-019-09620-4" target="_blank" >http://dx.doi.org/10.1007/s11101-019-09620-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11101-019-09620-4" target="_blank" >10.1007/s11101-019-09620-4</a>

Result language

angličtina

Original language name

Anti-cancer activities of cytokinin ribosides

Original language description

Cytokinins are plant hormones and play essential roles in regulating plant growth and development. They also have diverse pharmacological effects in animals and humans. Whereas cytokinin bases have been studied mainly for their cytoprotective activities, cytokinin ribosides have been explored as anti-cancer agents. Cytokinin ribosides inhibit growth or cause apoptosis in various cell lines derived from diverse malignancies including those with a mutant p53 gene. Activity against cancer stem cells, anti-angiogenic activity, and the ability to stimulate an immune response to malignant cells have been reported as well. There are also positive results from in vivo studies and reports of activity in patients with hematological malignancies and solid tumors. Here, we review studies of the anti-cancer activity of cytokinin ribosides since the 1960s and comment on the issues that need to be addressed for the further development of cytokinin ribosides into anti-cancer drugs.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Phytochemistry Reviews

ISSN

1568-7767

e-ISSN

—

Volume of the periodical

18

Issue of the periodical within the volume

4

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

13

Pages from-to

1101-1113

UT code for WoS article

000496695300007

EID of the result in the Scopus database

2-s2.0-85068869146