Plasma Membrane Domain Patterning and Self-Reinforcing Polarity in Arabidopsis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F20%3A00521442" target="_blank" >RIV/61389030:_____/20:00521442 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.devcel.2019.11.015" target="_blank" >http://dx.doi.org/10.1016/j.devcel.2019.11.015</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.devcel.2019.11.015" target="_blank" >10.1016/j.devcel.2019.11.015</a>

Result language
angličtina
Original language name
Plasma Membrane Domain Patterning and Self-Reinforcing Polarity in Arabidopsis
Original language description
Cell polarity is a key feature in the development of multicellular organisms. For instance, asymmetrically localized plasma-membrane-integral PIN-FORMED (PIN) proteins direct transcellular fluxes of the phytohormone auxin that govern plant development. Fine-tuned auxin flux is important for root protophloem sieve element differentiation and requires the interacting plasma-membrane-associated BREVIS RADIX (BRX) and PROTEIN KINASE ASSOCIATED WITH BRX (PAX) proteins. We observed donut-like polar PIN localization in developing sieve elements that depends on complementary, muffin-like polar localization of BRX and PAX. Plasma membrane association and polarity of PAX, and indirectly BRX, largely depends on phosphatidylinositol-4,5-bisphosphate. Consistently, mutants in phosphatidylinositol-4-phosphate 5-kinases (PIP5Ks) display protophloem differentiation defects similar to brx mutants. The same PIP5Ks are in complex with BRX and display muffin-like polar localization. Our data suggest that the BRX-PAX module recruits PIP5Ks to reinforce PAX polarity and thereby the polarity of all three proteins, which is required to maintain a local PIN minimum.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology

Project
<a href="/en/project/EF16_013%2F0001775" target="_blank" >EF16_013/0001775: Modernization and support of research activities of the national infrastructure for biological and medical imaging Czech-BioImaging</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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