New oxygen-containing androstane derivatives: Synthesis and biological potential

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F20%3A00532722" target="_blank" >RIV/61389030:_____/20:00532722 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/20:73604859
Result on the web
<a href="http://doi.org/10.1007/s12039-020-01803-3" target="_blank" >http://doi.org/10.1007/s12039-020-01803-3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s12039-020-01803-3" target="_blank" >10.1007/s12039-020-01803-3</a>

Result language
angličtina
Original language name
New oxygen-containing androstane derivatives: Synthesis and biological potential
Original language description
New steroidal D-homo androstane derivatives with 5 beta,6 beta-epoxy-3,16-dicarbonyl, 6 alpha- and 6 beta-hydroxy-3,16-dicarbonyl and 3 beta,5 alpha-dihydroxy-6,16-dicarbonyl moieties were synthesized and confirmed by NMR spectroscopy. Novel and starting compounds were evaluated for their potential cytotoxicityin vitroagainst seven human cancer cell lines (MCF-7, MDA-MB-231, PC3, HeLa, HT-29, A549 and CEM) and one human noncancerous cell line (MRC-5). The most sensitive cell line was MDA-MB-231 derived from female reproductive tissue, wherein all compounds showed moderate to strong cytotoxic activity. Also, new compound with 5 beta,6 beta-epoxy-3,16-dicarbonyl moieties showed strong cytotoxic activity against colon adenocarcinoma (HT-29). In this work,in silicoADME properties of novel compounds were assessed by comparing calculated molecular properties with Lipinski, Veber, Egan, Ghose and Muegge criteria. Graphic abstract The synthesis and structure elucidation of new oxygen-containing androstane derivatives was reported. New derivatives were tested for theirin silicoADME properties and cytotoxicity against different human cancer cell lines.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology

Project
<a href="/en/project/EF16_019%2F0000868" target="_blank" >EF16_019/0000868: Molecular, cellular and clinical approach to healthy ageing</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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