The role of UDP-glycosyltransferases in xenobioticresistance
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F22%3A00562796" target="_blank" >RIV/61389030:_____/22:00562796 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/22:10449961
Result on the web
<a href="https://doi.org/10.1080/03602532.2022.2083632" target="_blank" >https://doi.org/10.1080/03602532.2022.2083632</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/03602532.2022.2083632" target="_blank" >10.1080/03602532.2022.2083632</a>
Alternative languages
Result language
angličtina
Original language name
The role of UDP-glycosyltransferases in xenobioticresistance
Original language description
Uridine diphosphate sugar-utilizing glycosyltransferases (UGTs) are an enzyme superfamily that catalyzes glycosyl residues transfer from activated nucleotide sugars to acceptor molecules. In addition to various endogenous compounds, numerous xenobiotics are substrates of UGTs. As the glycosides formed are generally less active/toxic and more hydrophilic than aglycones, UGTs effectively protect organisms from potentially harmful xenobiotics. Therefore, increased UGT expression and/or activity improve the protection of the organism and may contribute to the development of individuals that become more resistant to certain xenobiotics. While the function of UGTs in the resistance of human cancer cells to chemotherapy is now well known, other organisms and other xenobiotics have attracted much less attention. This review was designed to fill this knowledge gap by presenting complex information about the role of UGTs in xenobiotic-resistance in various organisms. This summarization and evaluation of the available information reveals that UGTs play an important role in defense against xenobiotics not only in humans, but in countless other organisms such as parasites, insects, and plants. Moreover, many recent studies clearly show the participation of UGTs in the resistance of nematodes to anthelmintics, insects to insecticides, weeds to herbicides as well as humans to various drugs (not only those used in cancer therapy but also in the treatment of epilepsy, psychiatric disorders, hypertension, hypercholesterolemia, and HIV infection). Nevertheless, although the contribution of UGTs to xenobiotic resistance in diverse organisms has become obvious, many pieces of information remain missing, for example with regard to the mechanisms of UGT regulation.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10700 - Other natural sciences
Result continuities
Project
<a href="/en/project/EF19_073%2F0016935" target="_blank" >EF19_073/0016935: Grant schemes at Charles University</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Drug Metabolism Reviews
ISSN
0360-2532
e-ISSN
1097-9883
Volume of the periodical
54
Issue of the periodical within the volume
3
Country of publishing house
FR - FRANCE
Number of pages
17
Pages from-to
282-298
UT code for WoS article
000809721500001
EID of the result in the Scopus database
2-s2.0-85131744271