Naturally occurring eugenin: Biosynthesis, distribution, bioactivity, and therapeutic potential

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F24%3A00600419" target="_blank" >RIV/61389030:_____/24:00600419 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15310/24:73628607

Result on the web

<a href="https://doi.org/10.1016/j.phytol.2024.04.017" target="_blank" >https://doi.org/10.1016/j.phytol.2024.04.017</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.phytol.2024.04.017" target="_blank" >10.1016/j.phytol.2024.04.017</a>

Result language

angličtina

Original language name

Naturally occurring eugenin: Biosynthesis, distribution, bioactivity, and therapeutic potential

Original language description

Introduction: Eugenin (5-hydroxy-7-methoxy-2-methyl-4H-chromen-4-one) is a bioactive phytoalexin mainly found as a bitter component in carrots (Daucus carota L., Apiaceae) and cloves [Syzygium aromaticum (L.) Merr. & L. M. Perry, Myrtaceae]. Materials and methods: An extensive literature search was performed involving various established databases like Web of Science, PubMed, Science Direct, Dictionary of Natural Products and Google Scholar, using the keyword 'eugenin'. The literature reports that describe various aspects of naturally occurring eugenin, e.g., isolation, structure elucidation, biosynthesis, bioactivity studies and therapeutic potential, have been included in this review, while the papers that present total synthesis or structural modifications of eugenin have been excluded. Results: Eugenin, biosynthesized from the acetate-malonate pathway, has been reported from at least 22 plant species from 13 families. It has also been found in two fungal species, Aschersonia confluens and Chaetomium minutum. Dacaus carota and Syzygium aromaticum are two major sources of this chromone. Antimalarial, antimicrobial, antioxidant, antiplatelet aggregation, antiviral, cytotoxic, immunosuppressive/immunomodulatory, osteogenesis-inducing, pyrolyl endopeptidase (PEP)-inhibitory and blue-green algae growth inhibitory activities of eugenin have been reported in the literature. Among these bioactivities, antioxidant, antiplatelet aggregation, immunosuppressive/immunomodulatory activities of eugenin and its in silico prediction of antiviral property against severe-acute-respiratory-syndrome-related coronavirus-2 (SARS-CoV-2) activity may have some therapeutic potential. Conclusion: The distribution of eugenin is rather limited to a few plant species and only a couple of fungal species. Based on the reported bioactivities, it could be concluded that this chromone might have some potential as a template for new drug development.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30107 - Medicinal chemistry

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Phytochemistry Letters

ISSN

1874-3900

e-ISSN

1876-7486

Volume of the periodical

61

Issue of the periodical within the volume

JUN

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

7

Pages from-to

191-197

UT code for WoS article

001242295200001

EID of the result in the Scopus database

2-s2.0-85192454783