Identification and therapeutic efficacy of Pleurotus djamor var fuscopruinosus
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F25%3A00637606" target="_blank" >RIV/61389030:_____/25:00637606 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1038/s41598-025-02900-4" target="_blank" >https://doi.org/10.1038/s41598-025-02900-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-025-02900-4" target="_blank" >10.1038/s41598-025-02900-4</a>
Alternative languages
Result language
angličtina
Original language name
Identification and therapeutic efficacy of Pleurotus djamor var fuscopruinosus
Original language description
Pleurotus is an edible mushroom that is consumed and cultivated worldwide. Pleurotus djamor var. fuscopruinosus is newly reported in Thailand, confirmed through morphological and phylogenetic analyses. Cultivation trials showed optimal mycelial growth on PDA, with sorghum supporting the highest spawn production. Sawdust was a suitable substrate, with fruiting bodies forming at 25-28 degrees C and 70-80% humidity, maturing within 4-5 days. Nutritional analysis (per 100 g dry weight) revealed 25.00 +/- 1.5% protein, 15.99 +/- 0.2% carbohydrates, 19.10 +/- 0.9% fiber, 7.59 +/- 1.0% ash, 2.07 +/- 0.5% fat, and 30.25 +/- 0.5% moisture. The 50% ethyl acetate extract exhibited the strongest antioxidant activity (IC50: 694.47 +/- 3.92 mu g/mL for DPPH, 652.92 +/- 2.53 mu g/mL for ABTS). The extract showed selective cytotoxicity against lung (A549, IC50 = 245.73 +/- 7.60 mu g/mL) and colorectal (SW480, IC50 = 382.03 +/- 4.55 mu g/mL) cancer cells but was less potent than doxorubicin (IC50 = 14.96 +/- 1.58 mu g/mL). Moderate cytotoxicity was observed in RAW 264.7 macrophages (IC50 = 213.08 +/- 4.08 mu g/mL). Antidiabetic potential was demonstrated through alpha-glucosidase inhibition, with the hot water extract (IC50 = 582.91 +/- 3.0 mu g/mL) showing the highest activity, followed by ethyl acetate (IC50 = 473.87 +/- 1.4 mu g/mL) and methanol (IC50 = 357.63 +/- 3.3 mu g/mL), comparable to acarbose (IC50 = 635.70 +/- 4.9 mu g/mL). Glucose consumption in 3T3-L1 adipocytes was enhanced (IC50 = 582.91 +/- 3.0 mu g/mL) but lower than metformin (IC50 = 99.58 +/- 0.59 mu g/mL). These results highlight P. djamor var. fuscopruinosus as a promising functional food with strong antioxidant, anticancer effects, and antidiabetic properties. Further studies should optimize cultivation, isolate bioactive compounds, assess safety, and validate therapeutic properties through in vivo studies.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Reports
ISSN
2045-2322
e-ISSN
2045-2322
Volume of the periodical
15
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
20
Pages from-to
18929
UT code for WoS article
001499347000029
EID of the result in the Scopus database
2-s2.0-105006932397