RT-QuIC: a highly promising diagnostic method for neurodegenerative diseases-advantages and limitations
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F25%3A00637642" target="_blank" >RIV/61389030:_____/25:00637642 - isvavai.cz</a>
Alternative codes found
RIV/00098892:_____/25:10159361 RIV/61989592:15110/25:73631074 RIV/61989592:15310/25:73631074
Result on the web
<a href="https://doi.org/10.3389/fneur.2025.1578252" target="_blank" >https://doi.org/10.3389/fneur.2025.1578252</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fneur.2025.1578252" target="_blank" >10.3389/fneur.2025.1578252</a>
Alternative languages
Result language
angličtina
Original language name
RT-QuIC: a highly promising diagnostic method for neurodegenerative diseases-advantages and limitations
Original language description
Although it has been more than 200 years since Parkinson's disease was described, we have not established biomarkers for its definitive diagnosis yet. Moreover, there is a similar case for the entire group of alpha-synucleinopathies, which are all characterized by the pathological accumulation of aggregated alpha-synuclein (alpha-Syn) in the brain and other tissues. In different biological materials (blood, cerebrospinal fluid, saliva, or skin), alpha-Syn exists in various conformations and various aggregated states depending on the surrounding environment. Lewy bodies have been considered a pathognomonic feature of Parkinson's disease for over 100 years, and alpha-Syn has been known to be a key component of Lewy bodies for over 25 years, making it possible to confirm the diagnosis by post-mortem examination of brain tissue. To overcome these limitations, novel analytical seed amplification assays (SAAs) were introduced, and they quickly became one of the most effective diagnostic tools for antemortem detection of alpha-synucleinopathies. As they require minimal sample amounts to provide consistent, rapid, and reliable results, SAAs are ideally suited for biomarker determination. This review examines SAA analytical and detection methods, their advantages and strengths, as well as their limitations and shortcomings that need to be addressed to establish a reliable and reproducible protocol. This could serve as a diagnostic methodology worldwide to determine the presence of pathological alpha-Syn protein at early stages and help develop effective disease-modifying treatment.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Neurology
ISSN
1664-2295
e-ISSN
1664-2295
Volume of the periodical
16
Issue of the periodical within the volume
MAY 27
Country of publishing house
CH - SWITZERLAND
Number of pages
11
Pages from-to
1578252
UT code for WoS article
001504737600001
EID of the result in the Scopus database
2-s2.0-105007806599