Gibberellin- deactivating GA2OX enzymes act as a hub for auxin-gibberellin cross talk in Arabidopsis thaliana root growth regulation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F25%3A00638724" target="_blank" >RIV/61389030:_____/25:00638724 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/25:10500938 RIV/61989592:15310/25:73634799
Result on the web
<a href="https://doi.org/10.1073/pnas.2425574122" target="_blank" >https://doi.org/10.1073/pnas.2425574122</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1073/pnas.2425574122" target="_blank" >10.1073/pnas.2425574122</a>
Alternative languages
Result language
angličtina
Original language name
Gibberellin- deactivating GA2OX enzymes act as a hub for auxin-gibberellin cross talk in Arabidopsis thaliana root growth regulation
Original language description
Plant bodies are built from immobile cells, making the regulation of cell expansion essential for growth, development, and adaptation. In roots, cell elongation executes the movement of the root tips through the soil. This process is tightly controlled by numerous signaling pathways. Among these, gibberellin and auxin signaling stand out for their contrasting effects on root growth, interacting through complex cross talk at multiple regulatory levels. Here, we reveal the molecular basis of the auxin-gibberellin cross talk in the model plant Arabidopsis thaliana. We show that the auxin signaling pathway steers the expression of GIBBERELLIN2-OXIDASES (GA2OXs), key gibberellin-deactivating enzymes in the root elongation zone (EZ). GA2OXs are negative regulators of root cell elongation, GA2OX8 overexpression decreases gibberellin levels and inhibits root cell elongation, in contrast, the ga2ox heptuple mutant roots show elevated gibberellin levels in the EZ and grow longer roots. Intriguingly, shoot-derived auxin can regulate GA2OX6 and GA2OX8 expression in roots, linking systemic auxin signaling to local gibberellin level modulation. Together, our findings identify GA2OX6 and GA2OX8 enzymes as key mediators of auxin-gibberellin cross talk, providing insights into their roles in root elongation. These results expand our understanding of how auxin integrates with gibberellin signaling to coordinate root development and growth dynamics.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-8424
e-ISSN
1091-6490
Volume of the periodical
122
Issue of the periodical within the volume
30
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
e2425574122
UT code for WoS article
001543977200001
EID of the result in the Scopus database
2-s2.0-105012218504