Pm6 from Triticum timopheevii encodes an NLR receptor that directly recognizes AvrPm6 to confer powdery mildew resistance in wheat
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F25%3A00642573" target="_blank" >RIV/61389030:_____/25:00642573 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.molp.2025.10.012" target="_blank" >https://doi.org/10.1016/j.molp.2025.10.012</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.molp.2025.10.012" target="_blank" >10.1016/j.molp.2025.10.012</a>
Alternative languages
Result language
angličtina
Original language name
Pm6 from Triticum timopheevii encodes an NLR receptor that directly recognizes AvrPm6 to confer powdery mildew resistance in wheat
Original language description
The study reports the successful cloning and functional characterization of the wheat powdery mildew resistance gene Pm6, originating from Triticum timopheevii. Using map-based cloning, chromosome sorting, EMS mutagenesis, and transcriptomic analysis, the authors identify TraesLAC2B03G00988960 as the gene underlying Pm6, encoding an NLR-type immune receptor with a C-terminal PRK domain. The research further reveals the corresponding fungal effector AvrPm6, identified through genome-wide association analysis of Blumeria graminis f. sp. tritici isolates. Biochemical assays demonstrate a direct physical interaction between Pm6 and AvrPm6, which triggers immune activation, reactive oxygen species accumulation, and cell death. Functional validation through gene silencing, overexpression, and gene-editing confirms that Pm6-mediated resistance is strictly dependent on this AvrPm6 recognition. The findings elucidate a previously unknown effector–receptor pair in wheat immunity and provide valuable resources for resistance breeding and engineering of durable disease resistance.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular Plant
ISSN
1674-2052
e-ISSN
1752-9867
Volume of the periodical
18
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
2040-2044
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-105022901666