Progress, challenges, and opportunities in the field of biosynthetic reactions involving ambimodal transition states

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F26%3A00646776" target="_blank" >RIV/61389030:_____/26:00646776 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1039/d5np00064e" target="_blank" >https://doi.org/10.1039/d5np00064e</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/d5np00064e" target="_blank" >10.1039/d5np00064e</a>

Result language

angličtina

Original language name

Progress, challenges, and opportunities in the field of biosynthetic reactions involving ambimodal transition states

Original language description

High selectivity is generally observed in the biosynthesis of complex natural molecules. Evolution usually leads to enzymes that favor the formation of a particular isomer rather than one of the many other potential molecules. Recent discoveries of enzymes with multiple sequential post-transition state bifurcations (PTSB) after ambimodal transition states demonstrate the impact of dynamics on selectivity. PTSB cause a single ambimodal transition state (TS) to form multiple products. This is different from conventional energetically-controlled mechanisms, where two discrete transition states have different energy barriers. Selectivity arising from ambimodal TSs cannot be fully explained by transition state theory. The presence of PTSB on enzyme catalyzed reaction surfaces has been discovered recently at a significantly higher rate. For both uncatalyzed and catalyzed reactions, computational chemists are devising techniques to comprehend which elements of molecular structure and vibrations govern the product selectivity in systems that contain bifurcations. This review describes enzyme-catalyzed reactions involving ambimodal transition states, and recent advances in understanding how enzymes control selectivity in such reactions.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2026

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Natural Product Reports

ISSN

0265-0568

e-ISSN

1460-4752

Volume of the periodical

43

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

7-19

UT code for WoS article

001616427900001

EID of the result in the Scopus database

2-s2.0-105028871020