Evaluation and comperison of therapeutic monitoring of whole-blood levels of cyclosporin A and its metabolites in renal transplantation by HPLC and RIA methods.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F01%3A00000003" target="_blank" >RIV/61988987:17110/01:00000003 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

čeština

Original language name

Evaluation and comperison of therapeutic monitoring of whole-blood levels of cyclosporin A and its metabolites in renal transplantation by HPLC and RIA methods.

Original language description

The aim of the work was to evaluate the possibilitty to estimate the level of cyclosporin A CyA metabolites as the difference of radioimmunoassay RIA non-specific and RIA specific methods: RIA specific method,RIA non-specific method,and high performanceliquid chromathograpdy method.Although values obtained by RIAsp correlated well those obtained by HPLC,the results of HPLC methods were lower by 8%. The values obtained by RIAns were 2,57 times higher than the values obtained by RIAsp.The combination ofboth the specific and non-specific methods for the determination of CyA presents an improved means for the TDM of CyA and CyA metabolites in renal transplant patients.Moreover,a combination of both methods can help to elucidate some unexpected events,such as the persistence of high cyclosporin blood levels.

Czech name

Evaluation and comperison of therapeutic monitoring of whole-blood levels of cyclosporin A and its metabolites in renal transplantation by HPLC and RIA methods.

Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/OC%20B15.20" target="_blank" >OC B15.20: Plasma level of cyclosporine A and its metabolites and incidence of unwanted effects (hypertension, renal toxicity, graft rejection) in transplant patients. A Pk/Pd modelling.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2001

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinica Chemica Acta 310

ISSN

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e-ISSN

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Volume of the periodical

20

Issue of the periodical within the volume

2

Country of publishing house

AS - AMERICAN SAMOA

Number of pages

226

Pages from-to

165-171

UT code for WoS article

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EID of the result in the Scopus database

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