Significant discrepancy in cyclosporin A post-dose concentrations when analyzed with specific RIA and HPLC method

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F10%3AA1000XT4" target="_blank" >RIV/61988987:17110/10:A1000XT4 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/10:10214981

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Significant discrepancy in cyclosporin A post-dose concentrations when analyzed with specific RIA and HPLC method

Original language description

C-2 or AUC sparse sampling methods are widely recommended for therapeutic monitoring of cyclosporin A (CsA). One additional reason for promoting the C-2 sampling time in place of commonly used C-0 is that the C-2 level may actually provide more accuratemeasurement of parent drug concentration by immunoassays, as lower portion of metabolites has been formed 2 hours post-dose than at the steady-state trough time point. HPLC and RIA whole blood levels of CsA and its main metabolites AM1, AM9 and AWN werecompared during 12 hours profile after chronic administration.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

INT J CLIN PHARM TH

ISSN

0946-1965

e-ISSN

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Volume of the periodical

48

Issue of the periodical within the volume

2

Country of publishing house

DE - GERMANY

Number of pages

6

Pages from-to

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UT code for WoS article

000274770100001

EID of the result in the Scopus database

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