Validation of Sparse Sampling Strateies to Estimate Cyclosporine A Area Under the Concentation-Time Curve Using Either a Specific Radioimmunoassay or Hign-Performance Liquid Chromography Method
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F10%3AA110107H" target="_blank" >RIV/61988987:17110/10:A110107H - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Validation of Sparse Sampling Strateies to Estimate Cyclosporine A Area Under the Concentation-Time Curve Using Either a Specific Radioimmunoassay or Hign-Performance Liquid Chromography Method
Original language description
Area under the concentration-time curve (AUC) has been advocated as a better parameter to monitor cyclosporine A than trough concentrations. U to now, more thal 100 equations to estimate AUC using a limited sampling strategy have been published, but nothave been validated. Eight equations for AUC o-12h and two for AUC 0-8h were validated. Concetrations of cyclosporine A were analyzed by high-performance liquid chromatograhpy (HPLC) and a specific radioimmunoassay (RIA) method. Forty male renal transplant patients were included in the study. Blood samples were taken predose and at 0,5, 1, 1,5, 2, 3, 5, 8, and 12 hours after the morning dose when the patient was in steady state. The percentage prediction error (%pe) was used for an assessment of the performance of the equations. Mean %pe less than +/- and absolute %pe lees than 30% in 95% of predictions were considered to be acceptable. Other possibilities such as %pe less than 25%, 20ˇand 15ˇwere also tested.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
THER DRUG MONIT
ISSN
0163-4356
e-ISSN
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Volume of the periodical
32
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
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UT code for WoS article
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EID of the result in the Scopus database
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