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Validation of sparse sampling strategies to estimate cyclosporine A area under the concentration-time curve using either a specific radioimmunoassay or high-performance liquid chromography method

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F10%3A00101521" target="_blank" >RIV/00843989:_____/10:00101521 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1097/FTD.0b013e3181ed59fe" target="_blank" >http://dx.doi.org/10.1097/FTD.0b013e3181ed59fe</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1097/FTD.0b013e3181ed59fe" target="_blank" >10.1097/FTD.0b013e3181ed59fe</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Validation of sparse sampling strategies to estimate cyclosporine A area under the concentration-time curve using either a specific radioimmunoassay or high-performance liquid chromography method

  • Original language description

    Abstract: Introduction: Area under the concentration-time curve (AUC) has been advocated as a better parameter to monitor cyclosporine A than trough concentrations. Up to now, more than 100 equations to estimate AUC using a limited sampling strategy havebeen published, but not all have been validated. Material and Methods: Eight equations for AUC(0-12h) and two for AUC(0-8h) were validated. Concentrations of cyclosporine A were analyzed by high-performance liquid chromatography (HPLC) and a specific radioimmunoassay (RIA) method. Forty male renal transplant patients were included in the study. Blood samples were taken predose and at 0.5, 1, 1.5, 2, 3, 5, 8, and 12 hours after the morning dose when the patient was in steady state. The percentage prediction error (%pe) was used for an assessment of the performance of the equations. Mean %pe less than +/- 15% and absolute %pe less than 30% in 95% of predictions were considered to be acceptable. Other possibilities such as %pe less than 2

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FR - Pharmacology and apothecary chemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/1A8655" target="_blank" >1A8655: New Possibilities of TDM of Cyclosporine A and its Metabolites after kidney transplantation</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2010

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Therapeutic drug monitoring

  • ISSN

    0163-4356

  • e-ISSN

  • Volume of the periodical

    32

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    8

  • Pages from-to

    586-593

  • UT code for WoS article

    000282099700009

  • EID of the result in the Scopus database