Validation of sparse sampling strategies to estimate cyclosporine A area under the concentration-time curve using either a specific radioimmunoassay or high-performance liquid chromography method
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F10%3A00101521" target="_blank" >RIV/00843989:_____/10:00101521 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1097/FTD.0b013e3181ed59fe" target="_blank" >http://dx.doi.org/10.1097/FTD.0b013e3181ed59fe</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/FTD.0b013e3181ed59fe" target="_blank" >10.1097/FTD.0b013e3181ed59fe</a>
Alternative languages
Result language
angličtina
Original language name
Validation of sparse sampling strategies to estimate cyclosporine A area under the concentration-time curve using either a specific radioimmunoassay or high-performance liquid chromography method
Original language description
Abstract: Introduction: Area under the concentration-time curve (AUC) has been advocated as a better parameter to monitor cyclosporine A than trough concentrations. Up to now, more than 100 equations to estimate AUC using a limited sampling strategy havebeen published, but not all have been validated. Material and Methods: Eight equations for AUC(0-12h) and two for AUC(0-8h) were validated. Concentrations of cyclosporine A were analyzed by high-performance liquid chromatography (HPLC) and a specific radioimmunoassay (RIA) method. Forty male renal transplant patients were included in the study. Blood samples were taken predose and at 0.5, 1, 1.5, 2, 3, 5, 8, and 12 hours after the morning dose when the patient was in steady state. The percentage prediction error (%pe) was used for an assessment of the performance of the equations. Mean %pe less than +/- 15% and absolute %pe less than 30% in 95% of predictions were considered to be acceptable. Other possibilities such as %pe less than 2
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/1A8655" target="_blank" >1A8655: New Possibilities of TDM of Cyclosporine A and its Metabolites after kidney transplantation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Therapeutic drug monitoring
ISSN
0163-4356
e-ISSN
—
Volume of the periodical
32
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
586-593
UT code for WoS article
000282099700009
EID of the result in the Scopus database
—