Serum levels of valproic acid during delivery in mothers and in umbilical cord-correlation with birth length and weight

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F15%3AA1601FK4" target="_blank" >RIV/61988987:17110/15:A1601FK4 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Serum levels of valproic acid during delivery in mothers and in umbilical cord-correlation with birth length and weight

Original language description

Maternal and umbilical cord serum levels were analyzed at delivery in a cohort of 58 women, between the years 1991-2013. The request forms for routine therapeutic drug monitoring were used as the data source. Maternal levels and dosing information were used for estimating the maternal apparent oral clearance and the paired umbilical cord and maternal levels for estimation of umbilical cord/maternal level ratios. Result. The levels varied from 5,3-59,5 mg/L in maternal and 5,4-72,1 mg/L in umbilical cordserum. The umbilical cord/maternal level ratios ranged from 0,64-2,49. Significant correlation was found between maternal and umbilical cord levels. Significant inverse correlations were found between birth length, and both maternal and umbilical cord levels in monotherapy.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomed Pap Med Univ Palacky Olomouc

ISSN

1213-8118

e-ISSN

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Volume of the periodical

159

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

569-575

UT code for WoS article

000366566700009

EID of the result in the Scopus database

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