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Serum levels of valproic acid during delivery in mothers and in umbilical cord-correlation with birth length and weight

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F15%3AA1601FK4" target="_blank" >RIV/61988987:17110/15:A1601FK4 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Serum levels of valproic acid during delivery in mothers and in umbilical cord-correlation with birth length and weight

  • Original language description

    Maternal and umbilical cord serum levels were analyzed at delivery in a cohort of 58 women, between the years 1991-2013. The request forms for routine therapeutic drug monitoring were used as the data source. Maternal levels and dosing information were used for estimating the maternal apparent oral clearance and the paired umbilical cord and maternal levels for estimation of umbilical cord/maternal level ratios. Result. The levels varied from 5,3-59,5 mg/L in maternal and 5,4-72,1 mg/L in umbilical cordserum. The umbilical cord/maternal level ratios ranged from 0,64-2,49. Significant correlation was found between maternal and umbilical cord levels. Significant inverse correlations were found between birth length, and both maternal and umbilical cord levels in monotherapy.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FR - Pharmacology and apothecary chemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Biomed Pap Med Univ Palacky Olomouc

  • ISSN

    1213-8118

  • e-ISSN

  • Volume of the periodical

    159

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    6

  • Pages from-to

    569-575

  • UT code for WoS article

    000366566700009

  • EID of the result in the Scopus database