Brain Activity on fMRI Associated With Urinary Bladder Filling in Patients with a Complete Spinal Cord Injury

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F17%3AA1801QOI" target="_blank" >RIV/61988987:17110/17:A1801QOI - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/17:10359452 RIV/00216208:11120/17:43912820 RIV/00843989:_____/17:E0105800 RIV/00023001:_____/17:00060292 RIV/00064190:_____/17:N0000090

Result on the web

<a href="http://dx.doi.org/10.1002/nau.22901" target="_blank" >http://dx.doi.org/10.1002/nau.22901</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/nau.22901" target="_blank" >10.1002/nau.22901</a>

Result language

angličtina

Original language name

Brain Activity on fMRI Associated With Urinary Bladder Filling in Patients with a Complete Spinal Cord Injury

Original language description

Objective: Patients with complete spinal cord injury (SCI) may maintain some perception of bladder fullness. The aim of the study was to evaluate brain activation arising from anticipated extraspinal sensory pathways. Methods: Fourteen patients ages 24-54 years were enrolled, all having experienced a complete SCI (ASIA A) at C7 to T5 an average of 17 months before study entry. Urodynamic equipment was used for repeated bladder filling and detrusor activity evaluation. All functional magnetic resonance imaging measurements were performed using a Siemens Trio 3T scanner with the GRE-EPI sequence (field of view = 192 x 192 mm, voxel 3 x 3 x 3 mm, TR/TE = 3000/30 ms, 45 slices). Nine hundred dynamic scans were acquired over 45 min. Statistical analysis was done in SPM8 using a general linear model. Statistics using t-tests were thresholded at P = 0.001. Results: We excluded results from two patients because of activation artifacts. In 8 of 12 patients, significant brain activity was observed during urinary bladder filling. We found significant activation clusters at the nucleus of the solitary tract (NTS) (3/8), parabrachial nucleus (PBN) (4/8), hypothalamus (4/8), thalamus (6/8), amygdala (7/8), insular lobe (5/8), anterior cingulate gyrus (5/8), and prefrontal cortex (8/8). Activations in nuclei involved in afferents likely from the vagal nerve (NTS and PBN) correlated significantly with reported bladder sensations. Conclusions: These data suggest that extraspinal sensory pathways may develop following SCI and that vagal nerve may play a role in re-innervation of the urinary bladder. (C) 2015 Wiley Periodicals, Inc.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30217 - Urology and nephrology

Project

<a href="/en/project/NT14183" target="_blank" >NT14183: Mapping of brain activity during the filling and emptying of the urinary bladder using the functional magnetic resonance imaging</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neurourology and Urodynamics

ISSN

0733-2467

e-ISSN

—

Volume of the periodical

36

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

155-159

UT code for WoS article

000394666500024

EID of the result in the Scopus database

2-s2.0-84949871150