Biomarkers in immunoglobulin light chain amyloidosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F17%3AA1801R4R" target="_blank" >RIV/61988987:17110/17:A1801R4R - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/17:00098262 RIV/00216208:11110/17:10365703 RIV/65269705:_____/17:00067299 RIV/00843989:_____/17:E0106564 and 2 more
Result on the web
<a href="http://dx.doi.org/10.14735/amko20172S60" target="_blank" >http://dx.doi.org/10.14735/amko20172S60</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.14735/amko20172S60" target="_blank" >10.14735/amko20172S60</a>
Alternative languages
Result language
angličtina
Original language name
Biomarkers in immunoglobulin light chain amyloidosis
Original language description
Immunoglobulin light chain amyloidosis (AL amyloidosis - ALA) is a monoclonal gammopathy characterized by presence of aberrant plasma cells producing amyloidogenic immunoglobulin light chains. This leads to formation of amyloid fibrils in various organs and tissues, mainly in heart and kidney, and causes their dysfunction. As amyloid depositing in target organs is irreversible, there is a big effort to identify bio marker that could help to distinguish ALA from other monoclonal gammopathies in the early stages of disease, when amyloid deposits are not fatal yet. High throughput technologies bring new opportunities to modern cancer research as they enable to study disease within its complexity. Sophisticated methods such as next generation sequencing, gene expression profiling and circulating microRNA profiling are new approaches to study aberrant plasma cells from patients with light chain amyloidosis and related diseases. While generally known mutation in multiple myeloma patients (KRAS, NRAS, MYC, TP53) were not found in ALA, number of mutated genes is comparable. Transcriptome of ALA patients proves to be more similar to monoclonal gammopathy of undetermined significance patients, moreover level of circulating microRNA, that are known to correlate with heart damage, is increased in ALA patients, where heart damage in ALA typical symptom.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Klinicka Onkologie
ISSN
0862-495X
e-ISSN
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Volume of the periodical
30
Issue of the periodical within the volume
13. 7. 2017
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
8
Pages from-to
60-67
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-85029484418