Heterogenous mutation spectrum and deregulated cellular pathways in aberrant plasma cells underline molecular pathology of light-chain amyloidosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F21%3AA22028RK" target="_blank" >RIV/61988987:17110/21:A22028RK - isvavai.cz</a>
Alternative codes found
RIV/00669806:_____/21:10427706 RIV/00843989:_____/21:E0108826 RIV/00216208:11140/21:10427706 RIV/65269705:_____/21:00074366 and 3 more
Result on the web
<a href="https://haematologica.org/article/view/9744" target="_blank" >https://haematologica.org/article/view/9744</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3324/haematol.2019.239756" target="_blank" >10.3324/haematol.2019.239756</a>
Alternative languages
Result language
angličtina
Original language name
Heterogenous mutation spectrum and deregulated cellular pathways in aberrant plasma cells underline molecular pathology of light-chain amyloidosis
Original language description
Light-chain (AL) amyloidosis (ALA) is a rare but fatal monoclonal gammopathy (MG) causing organ and tissue damage resulting from the deposition of misfolded immunoglobulin free light chains in the form of amyloid fibrils.1 In some cases, ALA coexists with multiple myeloma (MM) (ALA+MM), which is the second most common blood cancer and is caused by the proliferation of clonal plasma cells (PC).2 Due to insufficient knowledge of ALA and ALA+MM biology, therapeutic options have mirrored treatment regimens of MM, which focus on the elimination of clonal PC.3,4 We investigated the mutation and gene expression profiles in clonal aberrant PC (aPC) in order to better understand ALA and ALA+MM etiology and to clarify the molecular differences between individual MG diagnoses.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30205 - Hematology
Result continuities
Project
<a href="/en/project/NV15-29667A" target="_blank" >NV15-29667A: Aberrant plasma cells clonal diversification in immunoglobulin light chain amyloidosis</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
HAEMATOL-HEMATOL J
ISSN
0390-6078
e-ISSN
1592-8721
Volume of the periodical
106
Issue of the periodical within the volume
2
Country of publishing house
IT - ITALY
Number of pages
4
Pages from-to
601-604
UT code for WoS article
000615767000010
EID of the result in the Scopus database
2-s2.0-85100634389