Raman microspectroscopy as a useful tool for nanopathology
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F17%3AA1801RC5" target="_blank" >RIV/61988987:17110/17:A1801RC5 - isvavai.cz</a>
Alternative codes found
RIV/61989100:27640/17:86098436 RIV/61989100:27740/17:86098436 RIV/00843989:_____/17:E0106163
Result on the web
<a href="http://dx.doi.org/10.1002/jrs.5045" target="_blank" >http://dx.doi.org/10.1002/jrs.5045</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jrs.5045" target="_blank" >10.1002/jrs.5045</a>
Alternative languages
Result language
angličtina
Original language name
Raman microspectroscopy as a useful tool for nanopathology
Original language description
Interactions between organisms and micro-and nano-sized particles are studied in a relatively new research fieldnanopathology. Some diseases (oncological and/or inflammatory) may be connected with accumulation of the particles in the tissues. In general, precise and accurate qualitative evaluation of chemical composition of particles is very important. In such analyses, scanning electron microscopy with energy dispersive X-ray spectroscopy is used most often. Nevertheless, it reveals merely the elemental composition of particles/clusters. On the other hand, because Raman microspectroscopy is nondestructive and it is coupled with an optical microscope, it has potential for detection of particles of unknown nature; in addition, it allows determination of the chemical composition of these particles/clusters. Therefore, this technique could be a very useful supporting tool for nanopathology. The aim of the presented study is to survey the possibilities and advantages of Raman microspectroscopy for the detection and characterization of particles of an unknown nature in the samples of human nasal mucosa and amniotic fluids. Three different approaches of analysis are hereby discussed: (1) analysis of the entire area of the sample, (2) division of the sample in sections, and subsequent analysis of a defined number of points in selected parts, and (3) Raman spectral imaging of the selected parts. Results clearly prove high efficiency of Raman microspectroscopy as a tool for characterization of the particles/clusters in human tissues and body fluids, and thus it may allow a better understanding of the potential impact to human health in relation to specific diagnoses. Copyright (c) 2016 John Wiley & Sons, Ltd.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JOURNAL OF RAMAN SPECTROSCOPY
ISSN
0377-0486
e-ISSN
1097-4555
Volume of the periodical
48
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
357-362
UT code for WoS article
000396657800001
EID of the result in the Scopus database
2-s2.0-84991325407