Alarmins and Clinical Outcomes After Major Abdominal Surgery-A Prospective Study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F17%3AA1801RX9" target="_blank" >RIV/61988987:17110/17:A1801RX9 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/17:10334412 RIV/00843989:_____/17:E0106329 RIV/61383082:_____/18:00000404

Result on the web

<a href="http://dx.doi.org/10.1080/08941939.2016.1231855" target="_blank" >http://dx.doi.org/10.1080/08941939.2016.1231855</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/08941939.2016.1231855" target="_blank" >10.1080/08941939.2016.1231855</a>

Result language

angličtina

Original language name

Alarmins and Clinical Outcomes After Major Abdominal Surgery-A Prospective Study

Original language description

Purpose: Tissue injury causing immune response is an integral part of surgical procedure. Evaluation of the degree of surgical trauma could help to improve postoperative management and determine the clinical outcomes. Materials and Methods: We analyzed serum levels of alarmins, including S100A5, S100A6, S100A8, S100A9, S100A11, and S100A12; high-mobility group box 1; and heat-shock protein 70, after elective major abdominal surgery (n = 82). Blood samples were collected for three consecutive days after surgery. The goals were to evaluate the relationships among the serum levels of alarmins and selected surgical characteristics and to test potential of alarmins to predict the clinical outcomes. Results: Significant, positive correlations were found for high-mobility group box 1 with the length of surgery, blood loss, and intraoperative fluid intake for all three days of blood sampling. The protein S100A8 serum levels showed positive correlations with intensive care unit length of stay, 28-day and in-hospital mortality. The protein S100A12 serum levels had significant, positive correlations with intensive care unit length of stay, 28-day mortality, and in-hospital mortality. We did not find significant differences in alarmin levels between cancer and noncancer subjects. Conclusion: The high-mobility group box 1 serum levels reflect the degree of surgical injury, whereas proteins S100A8 and S100A12 might be considered good predictors of major abdominal surgery morbidity and mortality.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30221 - Critical care medicine and Emergency medicine

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JOURNAL OF INVESTIGATIVE SURGERY

ISSN

0894-1939

e-ISSN

1521-0553

Volume of the periodical

30

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

152-161

UT code for WoS article

000400299200002

EID of the result in the Scopus database

2-s2.0-84989271454