Alarmins as biomarkers of gastrointestinal surgical injury - a pilot study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F18%3AA1901S5P" target="_blank" >RIV/61988987:17110/18:A1901S5P - isvavai.cz</a>
Alternative codes found
RIV/61383082:_____/18:00000412 RIV/00216208:11110/18:10376355 RIV/00843989:_____/18:E0106920
Result on the web
<a href="http://dx.doi.org/10.1111/apm.12798" target="_blank" >http://dx.doi.org/10.1111/apm.12798</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/apm.12798" target="_blank" >10.1111/apm.12798</a>
Alternative languages
Result language
angličtina
Original language name
Alarmins as biomarkers of gastrointestinal surgical injury - a pilot study
Original language description
The dysregulation of inflammatory response to surgical injury affects outcomes. Alarmins, the earliest bioactive substances from damaged cells, play a crucial role in initiating the inflammation. We analyzed serum levels of alarmins (S100A8, S100A12, high mobility group box, and heat shock protein 70) after major abdominal surgery (MAS) in surgical (S) (n=82) and nonsurgical (NS) groups (n=35). The main objective was determining a role of selected alarmins in host response to MAS. The secondary objectives were (i) evaluation of the relationship among alarmins and selected biomarkers (C-reactive protein, interleukin-6), (ii) influence of the place of gastrointestinal resection, and (iii) role of alarmins in MAS for cancer. Except for HMGB1, the levels of all alarmins were higher in the S group compared with the NS group. In the S group, positive correlations were found between S100A8 and both IL-6 and CRP. Additionally, the S100A8 level was higher (p<0.01) in patients who underwent upper gastrointestinal tract (GIT) surgery compared to middle and lower GIT resections. Alarmins levels did not differ between cancer and noncancer patients. MAS is able to elicit increase in alarmin levels. S100A8 can be considered a potential biomarker of surgical injury, especially in the upper part of the GIT.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
APMIS
ISSN
0903-4641
e-ISSN
1600-0463
Volume of the periodical
126
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
152-159
UT code for WoS article
000423388400008
EID of the result in the Scopus database
2-s2.0-85041065598