Current applications of multiparameter flow cytometry in plasma cell disorders

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F17%3AA1801RYG" target="_blank" >RIV/61988987:17110/17:A1801RYG - isvavai.cz</a>

Alternative codes found

RIV/00843989:_____/17:E0106608 RIV/65269705:_____/17:00068637

Result on the web

<a href="http://dx.doi.org/10.1038/bcj.2017.90" target="_blank" >http://dx.doi.org/10.1038/bcj.2017.90</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/bcj.2017.90" target="_blank" >10.1038/bcj.2017.90</a>

Result language

angličtina

Original language name

Current applications of multiparameter flow cytometry in plasma cell disorders

Original language description

Multiparameter flow cytometry (MFC) has become standard in the management of patients with plasma cell (PC) dyscrasias, and could be considered mandatory in specific areas of routine clinical practice. It plays a significant role during the differential diagnostic workup because of its fast and conclusive readout of PC clonality, and simultaneously provides prognostic information in most monoclonal gammopathies. Recent advances in the treatment and outcomes of multiple myeloma led to the implementation of new response criteria, including minimal residual disease (MRD) status as one of the most relevant clinical endpoints with the potential to act as surrogate for survival. Recent technical progress led to the development of next-generation flow (NGF) cytometry that represents a validated, highly sensitive, cost-effective and widely available technique for standardized MRD evaluation, which also could be used for the detection of circulating tumor cells. Here we review current applications of MFC and NGF in most PC disorders including the less frequent solitary plasmocytoma, light-chain amyloidosis or Waldenstrom macroglobulinemia.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30205 - Hematology

Project

<a href="/en/project/NV17-30089A" target="_blank" >NV17-30089A: In-depth genomic analysis of residual clone in multiple myeloma: approach for individualized targeted therapy</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BLOOD CANCER JOURNAL

ISSN

2044-5385

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

10/2017

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

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UT code for WoS article

000413469800001

EID of the result in the Scopus database

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