Current applications of multiparameter flow cytometry in plasma cell disorders

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F17%3A00068637" target="_blank" >RIV/65269705:_____/17:00068637 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17110/17:A1801RYG RIV/00843989:_____/17:E0106608
Result on the web
<a href="http://www.nature.com/articles/bcj201790#change-history" target="_blank" >http://www.nature.com/articles/bcj201790#change-history</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/bcj.2017.90" target="_blank" >10.1038/bcj.2017.90</a>

Result language
angličtina
Original language name
Current applications of multiparameter flow cytometry in plasma cell disorders
Original language description
Multiparameter flow cytometry (MFC) has become standard in the management of patients with plasma cell (PC) dyscrasias, and could be considered mandatory in specific areas of routine clinical practice. It plays a significant role during the differential diagnostic workup because of its fast and conclusive readout of PC clonality, and simultaneously provides prognostic information in most monoclonal gammopathies. Recent advances in the treatment and outcomes of multiple myeloma led to the implementation of new response criteria, including minimal residual disease (MRD) status as one of the most relevant clinical endpoints with the potential to act as surrogate for survival. Recent technical progress led to the development of next-generation flow (NGF) cytometry that represents a validated, highly sensitive, cost-effective and widely available technique for standardized MRD evaluation, which also could be used for the detection of circulating tumor cells. Here we review current applications of MFC and NGF in most PC disorders including the less frequent solitary plasmocytoma, light-chain amyloidosis or Waldenstrom macroglobulinemia.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30204 - Oncology

Project
<a href="/en/project/NV17-30089A" target="_blank" >NV17-30089A: In-depth genomic analysis of residual clone in multiple myeloma: approach for individualized targeted therapy</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)