Survivin in breast lesions: immunohistochemical analysis of 196 cases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F17%3AA1801TQ0" target="_blank" >RIV/61988987:17110/17:A1801TQ0 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.5114/pjp.2017.73925" target="_blank" >http://dx.doi.org/10.5114/pjp.2017.73925</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5114/pjp.2017.73925" target="_blank" >10.5114/pjp.2017.73925</a>

Result language

angličtina

Original language name

Survivin in breast lesions: immunohistochemical analysis of 196 cases

Original language description

We examined the survivin expression pattern by immunohistochemistry in 43 fibroadenomas and 153 ductal carcinomas of the breast. The subcellular localization of survivin and the intensity of immunoreaction were assessed. We analyzed the differences of survivin expression between fibroadenomas and carcinomas. We also correlated the survivin expression pattern in carcinomas with other clinicomorphological parameters such as the age of patients, the grade and size of primary tumor as well as the lymph node metastasis. Overall, survivin was detected in 107/153 carcinomas (69.9%) and in 26/43 fibroadenomas (60.5%). Statistical analysis confirmed significant correlations between the assessed parameters in fibroadenomas and carcinomas. Grade of carcinomas was significantly related to survivin expression in both subcellular localization and the intensity of immunoreaction. Tumor grade 3 was associated with nuclear positivity and combined nuclear and cytoplasmic localization. Carcinomas larger than 20 mm showed nuclear and combined localization in 81% of cases and higher intensity of survivin immunoreaction was also notably related to larger carcinomas. Statistically significant differences were also observed between subcellular survivin localization and intensity of immunoreaction. Our result suggest that nuclear accumulation of survivin is associated with proliferative fenotype and survivin was shown to be a worse prognostic marker in breast ductal carcinoma.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30102 - Immunology

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Polish Journal of Pathology

ISSN

1233-9687

e-ISSN

—

Volume of the periodical

68

Issue of the periodical within the volume

4

Country of publishing house

PL - POLAND

Number of pages

9

Pages from-to

297-305

UT code for WoS article

000428126800004

EID of the result in the Scopus database

2-s2.0-85043314376