HbA1c but not diabetes duration predicts increased arterial stiffness in adolescents with poorly controlled type 1 diabetes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F17%3AA1801TW9" target="_blank" >RIV/61988987:17110/17:A1801TW9 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/17:10373808 RIV/00843989:_____/17:E0106327 RIV/00064203:_____/17:10373808

Result on the web

<a href="http://dx.doi.org/10.1111/pedi.12385" target="_blank" >http://dx.doi.org/10.1111/pedi.12385</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/pedi.12385" target="_blank" >10.1111/pedi.12385</a>

Result language

angličtina

Original language name

HbA1c but not diabetes duration predicts increased arterial stiffness in adolescents with poorly controlled type 1 diabetes

Original language description

Obermannova B, Petruzelkova L, Sulakova T, Sumnik Z. HbA1c but not diabetes duration predicts increased arterial stiffness in adolescents with poorly controlled type 1 diabetes. Pediatric Diabetes 2017: 18: 304-310.Background: The prevalence of macrovascular complications is probably underestimated in children with type 1 diabetes (T1D). Arterial stiffness (AS) is a subclinical marker of cardiovascular (CV) risk. The most validated, non-invasive method for AS measurement is pulse wave velocity (PWV). Only a few PWV studies have been performed in children with T1D.Objective: To explore the risk factors associated with AS in adolescents with suboptimally controlled T1D.Patients and methods: Seventy-seven adolescents with T1D were included (39 girls, 38 boys) in this study. The adolescents had a median age of 16 yr (IQR 14-17), median duration of T1D was 9 yr (IQR 6-16), and HbA1c 71 mmol/mol (median, IQR 62-81). PWV was measured as the carotid-femoral pulse transmission time and converted into standard deviation scores (SDS) (adjusted for gender and age) using normative values for children. The risk factors assessed were HbA1c, T1D duration, treatment modality, serum lipids, and blood pressure (BP) measured via ambulatory blood pressure monitoring (ABPM).Results: The PWV did not differ from the reference data (median PWV was 5.1m/s, i.e., -0.01 SDS). A significant positive association was observed between PWV-SDS and HbA1c (p=0.001), total cholesterol (p=0.003), LDL-cholesterol (p=0.003), but not T1D duration (p=0.78) according to the univariate analyses. In the multivariate model, the only significant variable that remained positively associated with PWV-SDS was HbA1c (p=0.03).Conclusions: Most adolescents with suboptimally controlled T1D have normal mean PWV compared to a healthy reference population. Chronic hyperglycemia, not T1D duration, is the main predictor of AS in adolescents.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

<a href="/en/project/NT14335" target="_blank" >NT14335: Arterial stiffness in children with diabetes mellitus type 1 - relationship between pulse wave velocity (PWV) and ambulatory arterial stiffness index (AASI)</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PEDIATRIC DIABETES

ISSN

1399-543X

e-ISSN

1399-5448

Volume of the periodical

6/2017

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

304-310

UT code for WoS article

000402892400008

EID of the result in the Scopus database

2-s2.0-84963800565