Chronobiological perspectives on myocardial electrophysiological parameters under three types of general anaesthesia in a rat model

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F17%3AA1901MHN" target="_blank" >RIV/61988987:17110/17:A1901MHN - isvavai.cz</a>

Result on the web

<a href="http://www.tandfonline.com/doi/full/10.1080/09291016.2016.1263003" target="_blank" >http://www.tandfonline.com/doi/full/10.1080/09291016.2016.1263003</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/09291016.2016.1263003" target="_blank" >10.1080/09291016.2016.1263003</a>

Result language

angličtina

Original language name

Chronobiological perspectives on myocardial electrophysiological parameters under three types of general anaesthesia in a rat model

Original language description

The specific aim of the present study, with respect to dependence on the light?dark (LD) cycle under in vivo conditions in spontaneously breathing rats was to review initial state in electrophysiological parameters that may predict the development of heart rhythm disorders in pentobarbital (40 mg/kg), ketamine?xylazine (100 + 15 mg/kg) and zoletil (30 mg/kg) anaesthetized animals. The study was performed using female Wistar rats that were adaptated to an LD cycle (12 h:12 h). Heart rate, PQ and QT intervals were evaluated for their dependence on the LD cycle. The longest PQ interval duration is under zoletil anaesthesia in the light period and the longest QT interval duration is under ketamine-xylazine anaesthesia in both light periods. We concluded that the most significant predisposition toward the development of ventricular arrhythmias originating from disorders of impulse production and conduction occurred under zoletil anaesthesia in the light period; those resulting from disorders in the dispersion of refractory periods occurred under ketamine-xylazine anaesthesia in both the light periods.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30105 - Physiology (including cytology)

Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biological rhythm research

ISSN

1744-4179

e-ISSN

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Volume of the periodical

48

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

344-351

UT code for WoS article

000399474500002

EID of the result in the Scopus database

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