Ketamine/xylazine anaesthesia in the chronobiological studies

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F14%3AA1501BT8" target="_blank" >RIV/61988987:17110/14:A1501BT8 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Ketamine/xylazine anaesthesia in the chronobiological studies
Original language description
Administration of anaesthesia during the daytime is important and may influence specific aspects of in vivo animal experiments. The aim of the present study was to refer to the suitability of the use of ketamine/xylazine anaesthesia in chronobiological studies. Study was performed in ketamine-/xylazine-anaesthetized female Wistar rats ( 100 mg/kg/15 mg/kg, i.m) after adaptation to a light-dark (LD) cycle ( 12 h: 12 h). Heart rate (HR), rectal temperature, ECG parameters, autonomic nervous system activity, acid-base balance and Na+, K+, Ca2+ and Cl(-)plasma concentrations were evaluated in dependence on LD cycle. LD differences were found in the HR, rectal temperature, RR, PQ and QTc intervals, QRS complex, P wave amplitude, in power HF, LF and VLF components, in paO2 and HCO3-, and in Na+, Cl(-)and Ca2+ ions. Ketamine/xylazine anaesthesia may be applicable in chronobiological studies. It does not disturb LD differences, but it can modify them probably without loss of rhythmicity.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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