Chronobiological Aspects of Ketamine/Xylazine Anaesthesia Impact on the Cardiovascular System, the Acid-base Balance, Ions and Autonomic Nervous System in Wistar Rats

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F13%3AA130173K" target="_blank" >RIV/61988987:17110/13:A130173K - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Chronobiological Aspects of Ketamine/Xylazine Anaesthesia Impact on the Cardiovascular System, the Acid-base Balance, Ions and Autonomic Nervous System in Wistar Rats
Original language description
The creation of experimental, in vivo, chronobiological animal models may help to reveal some of the relationships between circadian rhythmsand biological function, which is sometimes very difficult to study in humans.However, in vivo experiments requirethe use of appropriate anaesthesia, which should be selected according to their particular effect on the organism. Using an animal model, the aim of the present study was to evaluate the chronobiological effects of ketamine/xylazine anaesthesia in spontaneously breathing rats. Study was performed in female Wistar rats (10mg/kg/15mg/kg, i.m)after adaptation to a LD cycle of 12 hours light:12 hours dark. Heart rate, rectal temperature, electrocardiographic parameters, autonomic nervous system activity, acid-base balance and Na+, K+, Ca2+ and Cl- plasma concentrations in arterial blood were evaluated in their dependence on the active (dark) and non-active (light) parts of the LD cycle.
Czech name
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Czech description
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Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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