Prognostic indicators in primary plasma cell leukaemia: a multicentre retrospective study of 117 patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F18%3AA1901W58" target="_blank" >RIV/61988987:17110/18:A1901W58 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/18:10380677 RIV/00179906:_____/18:10380677 RIV/00843989:_____/18:E0107028
Result on the web
<a href="http://dx.doi.org/10.1111/bjh.15092" target="_blank" >http://dx.doi.org/10.1111/bjh.15092</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/bjh.15092" target="_blank" >10.1111/bjh.15092</a>
Alternative languages
Result language
angličtina
Original language name
Prognostic indicators in primary plasma cell leukaemia: a multicentre retrospective study of 117 patients
Original language description
We report a multicentre retrospective study that analysed clinical characteristics and outcomes in 117 patients with primary plasma cell leukaemia (pPCL) treated at the participating institutions between January 2006 and December 2016. The median age at the time of pPCL diagnosis was 61years. Ninety-eight patients were treated with novel agents, with an overall response rate of 78%. Fifty-five patients (64%) patients underwent upfront autologous stem cell transplantation (ASCT). The median follow-up time was 50months (95% confidence interval [CI] 33; 76), with a median overall survival (OS) for the entire group of 23 months (95% CI 15; 34). The median OS time in patients who underwent upfront ASCT was 35 months (95% CI 24.3; 46) as compared to 13 months (95% CI 6.3; 35.8) in patients who did not receive ASCT (P=0.001). Multivariate analyses identified age >= 60years, platelet count <= 100x10(9)/l and peripheral blood plasma cell count >= 20x10(9)/l as independent predictors of worse survival. The median OS in patients with 0, 1 or 2-3 of these risk factors was 46, 27 and 12months, respectively (P<0.001). Our findings support the use of novel agents and ASCT as frontline treatment in patients with pPCL. The constructed prognostic score should be independently validated.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30205 - Hematology
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BRITISH JOURNAL OF HAEMATOLOGY
ISSN
0007-1048
e-ISSN
1365-2141
Volume of the periodical
180
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
831-839
UT code for WoS article
000426607200008
EID of the result in the Scopus database
2-s2.0-85042936275