Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F18%3AA20020PJ" target="_blank" >RIV/61988987:17110/18:A20020PJ - isvavai.cz</a>

Result on the web

<a href="https://watermark.silverchair.com/bgx113.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAmcwggJjBgkqhkiG9w0BBwagggJUMIICUAIBADCCAkkGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM2int-F6YUD_hi8_ZAgEQgIICGk-01Ys0hFF9aBi8UHN23eb_7h-Kb5NUniSdezKTzBBlCpS" target="_blank" >https://watermark.silverchair.com/bgx113.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAmcwggJjBgkqhkiG9w0BBwagggJUMIICUAIBADCCAkkGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM2int-F6YUD_hi8_ZAgEQgIICGk-01Ys0hFF9aBi8UHN23eb_7h-Kb5NUniSdezKTzBBlCpS</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/carcin/bgx113" target="_blank" >10.1093/carcin/bgx113</a>

Result language

angličtina

Original language name

Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population

Original language description

Non-small cell lung cancer is the most common type of lung cancer. Both environmental and genetic risk factors contribute to lung carcinogenesis. We conducted a genome-wide interaction analysis between single nucleotide polymorphisms (SNPs) and smoking status (never-versus ever-smokers) in a European-descent population. We adopted a two-step analysis strategy in the discovery stage: we first conducted a case-only interaction analysis to assess the relationship between SNPs and smoking behavior using 13 336 non-small cell lung cancer cases. Candidate SNPs with P-value &lt;0.001 were further analyzed using a standard case-control interaction analysis including 13 970 controls. The significant SNPs with P-value &lt;3.5 x 10(-5) (correcting for multiple tests) from the case-control analysis in the discovery stage were further validated using an independent replication dataset comprising 5377 controls and 3054 non-small cell lung cancer cases. We further stratified the analysis by histological subtypes. Two novel SNPs, rs6441286 and rs17723637, were identified for overall lung cancer risk. The interaction odds ratio and meta-analysis P-value for these two SNPs were 1.24 with 6.96 x 10(-7) and 1.37 with 3.49 x 10(-7), respectively. In addition, interaction of smoking with rs4751674 was identified in squamous cell lung carcinoma with an odds ratio of 0.58 and P-value of 8.12 x 10(-7). This study is by far the largest genome-wide SNP-smoking interaction analysis reported for lung cancer. The three identified novel SNPs provide potential candidate biomarkers for lung cancer risk screening and intervention. The results from our study reinforce that gene-smoking interactions play important roles in the etiology of lung cancer and account for part of the missing heritability of this disease.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30204 - Oncology

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

CARCINOGENESIS

ISSN

0143-3334

e-ISSN

1460-2180

Volume of the periodical

39

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

336-346

UT code for WoS article

000427120100004

EID of the result in the Scopus database

2-s2.0-85043592947