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Effect of Occupational Exposures on Lung Cancer Susceptibility: A Study of Gene-Environment Interaction Analysis

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10294931" target="_blank" >RIV/00216208:11110/15:10294931 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/15:00087034 RIV/61989592:15110/15:33154950 RIV/00209805:_____/15:#0000696

  • Result on the web

    <a href="http://dx.doi.org/10.1158/1055-9965.EPI-14-1143-T" target="_blank" >http://dx.doi.org/10.1158/1055-9965.EPI-14-1143-T</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1158/1055-9965.EPI-14-1143-T" target="_blank" >10.1158/1055-9965.EPI-14-1143-T</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Effect of Occupational Exposures on Lung Cancer Susceptibility: A Study of Gene-Environment Interaction Analysis

  • Original language description

    Background: Occupational exposures are known risk factors for lung cancer. Role of genetically determined host factors in occupational exposure-related lung cancer is unclear. Methods: We used genome-wide association (GWA) data from a case-control studyconducted in 6 European countries from 1998 to 2002 to identify gene-occupation interactions and related pathways for lung cancer risk. GWA analysis was performed for each exposure using logistic regression and interaction term for genotypes, and exposure was included in this model. Both SNP-based and gene-based interaction P values were calculated. Pathway analysis was performed using three complementary methods, and analyses were adjusted for multiple comparisons. We analyzed 312,605 SNPs and occupational exposure to 70 agents from 1,802 lung cancer cases and 1,725 cancer-free controls. Results: Mean age of study participants was 60.1 +/- 9.1 years and 75% were male. Largest number of significant associations (P <= 1 x 10(-5)) at SNP

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FQ - Public health system, social medicine

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Cancer Epidemiology Biomarkers and Prevention

  • ISSN

    1055-9965

  • e-ISSN

  • Volume of the periodical

    24

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    10

  • Pages from-to

    570-579

  • UT code for WoS article

    000351953100013

  • EID of the result in the Scopus database

    2-s2.0-84927761476