Effect of Occupational Exposures on Lung Cancer Susceptibility: A Study of Gene-Environment Interaction Analysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10294931" target="_blank" >RIV/00216208:11110/15:10294931 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/15:00087034 RIV/61989592:15110/15:33154950 RIV/00209805:_____/15:#0000696
Result on the web
<a href="http://dx.doi.org/10.1158/1055-9965.EPI-14-1143-T" target="_blank" >http://dx.doi.org/10.1158/1055-9965.EPI-14-1143-T</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1158/1055-9965.EPI-14-1143-T" target="_blank" >10.1158/1055-9965.EPI-14-1143-T</a>
Alternative languages
Result language
angličtina
Original language name
Effect of Occupational Exposures on Lung Cancer Susceptibility: A Study of Gene-Environment Interaction Analysis
Original language description
Background: Occupational exposures are known risk factors for lung cancer. Role of genetically determined host factors in occupational exposure-related lung cancer is unclear. Methods: We used genome-wide association (GWA) data from a case-control studyconducted in 6 European countries from 1998 to 2002 to identify gene-occupation interactions and related pathways for lung cancer risk. GWA analysis was performed for each exposure using logistic regression and interaction term for genotypes, and exposure was included in this model. Both SNP-based and gene-based interaction P values were calculated. Pathway analysis was performed using three complementary methods, and analyses were adjusted for multiple comparisons. We analyzed 312,605 SNPs and occupational exposure to 70 agents from 1,802 lung cancer cases and 1,725 cancer-free controls. Results: Mean age of study participants was 60.1 +/- 9.1 years and 75% were male. Largest number of significant associations (P <= 1 x 10(-5)) at SNP
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FQ - Public health system, social medicine
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancer Epidemiology Biomarkers and Prevention
ISSN
1055-9965
e-ISSN
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Volume of the periodical
24
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
570-579
UT code for WoS article
000351953100013
EID of the result in the Scopus database
2-s2.0-84927761476