VAGAL MODULATION AND COGNITIVE DECLINE OVER 10 YEARS: THE WHITEHALL II COHORT STUDY
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F18%3AA20020RE" target="_blank" >RIV/61988987:17110/18:A20020RE - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
VAGAL MODULATION AND COGNITIVE DECLINE OVER 10 YEARS: THE WHITEHALL II COHORT STUDY
Original language description
Dysfunction of autonomic nervous system may contribute to neuronal damage. The research in this area is limited. We prospectively investigated whether decreased vagal modulation, indexed by high frequency heart rate variability (HF-HRV), in midlife predicts subsequent cognitive decline. Method: Data from the fifth (1997-1999), seventh (2002-2004) and ninth (2007-2009) phases of the UK Whitehall II longitudinal population-based cohort study were analysed. The sample size was 4471 (1247 women). Cognitive function measures included memory, reasoning, vocabulary, executive function and global cognition. Heart rate variability was obtained during 5 min of supine rest. The values of HF-HRV at phase 5 were divided into quartiles. Random mixed models were applied. Results: Over a 10 year period there was significantly greater decline in vocabulary (β=-0.15; p=0.001), reasoning, (β=-0.11; p=0.007), executive function (β=-0.09; p=0.033) and global cognition (β=-0.07; p=0.027 ) among men with baseline HF-HRV in the lowest quartile than others. Statistically insignificant associations were found in women. All models were adjusted for age, ethnicity and education. Further adjustments for known confounders including sociodemographic and lifestyle factors, cardiometabolic conditions and medication did not change the predictive effect of HRV on cognitive decline. Conclusion: Findings support an etiological role of the autonomic nervous system in cognitive decline.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
30302 - Epidemiology
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
PSYCHOSOMATIC MEDICINE
ISBN
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ISSN
0033-3174
e-ISSN
1534-7796
Number of pages
1
Pages from-to
12-12
Publisher name
LIPPINCOTT WILLIAMS & WILKINS, TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
Place of publication
PHILADELPHIA, PA 19103 USA
Event location
Louisville, KY
Event date
Jan 1, 2018
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000436027400027