Midlife heart rate variability and cognitive decline: A large longitudinal cohort study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17450%2F24%3AA2603B1D" target="_blank" >RIV/61988987:17450/24:A2603B1D - isvavai.cz</a>

Result on the web

<a href="https://linkinghub.elsevier.com/retrieve/pii/S1697260024000838" target="_blank" >https://linkinghub.elsevier.com/retrieve/pii/S1697260024000838</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijchp.2024.100518" target="_blank" >10.1016/j.ijchp.2024.100518</a>

Result language

angličtina

Original language name

Midlife heart rate variability and cognitive decline: A large longitudinal cohort study

Original language description

Background: Autonomic dysfunction is common in dementia, yet its contribution to neurocognitive changes re- mains unknown. We investigated whether midlife cardiac vagal modulation, indexed by heart rate variability, associates with subsequent cognitive decline in adults without prior coronary heart disease or stroke. Methods: The sample comprised 2702 (1924 men) individuals initially aged 44–69 years from the UK Whitehall II cohort. Data from the fifth (1997–1999), seventh (2002–2004) and ninth (2007–2009) phases were analysed. Global cognitive function was ascertained from tests assessing memory, reasoning, vocabulary, and fluency. We used 12-lead-ECG-based heart rate variability measures, that primarily reflect vagal modulation (i.e. RMSSD and HF-HRV). Linear mixed-effects models and logistic regression were employed. Results: Results showed consistent associations between both vagally-mediated HRV measures and faster decline in global cognitive function. Specifically, low RMSSD and HF-HRV (lowest versus upper four quintiles) were associated with 0.07 SD (95% CI: -0.13, -0.01) and 0.06 SD (95% CI: -0.12, -0.004) accelerated 10-year cognitive decline after sociodemographic adjustments and faster decline in older ages. Further adjustments for lifestyle factors, medication use and other cardiometabolic conditions did not change the findings. Cognitive decline in individuals with low RMSSD and HF-HRV was estimated to progress 3 and 3.5 years faster per decade, respectively, compared to their counterparts. Additionally, participants with low RMSSD had 37% higher odds of low cognitive function (lowest quintile) at follow-up (OR 1.37: 95% CI,1.03, 1.80). Conclusion: Our findings support the aetiological significance of the autonomic nervous system, specifically vagal modulation, in the processes of cognitive decline and neurodegeneration. Low heart rate variability emerges as a potential biomarker indicative of acclerated cognitive decline that may extend over decades

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

50100 - Psychology and cognitive sciences

Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Clinical and Health Psychology

ISSN

1697-2600

e-ISSN

2174-0852

Volume of the periodical

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Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

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UT code for WoS article

001361949300001

EID of the result in the Scopus database

2-s2.0-85209570073