Congenital heart defects according to the types of the risk factors - a single center experience

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F19%3AA200210C" target="_blank" >RIV/61988987:17110/19:A200210C - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/19:10399912 RIV/00179906:_____/19:10399912 RIV/00843989:_____/19:E0107887 RIV/61989592:15110/19:73587077

Result on the web

<a href="https://www.tandfonline.com/doi/full/10.1080/14767058.2018.1468883" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/14767058.2018.1468883</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/14767058.2018.1468883" target="_blank" >10.1080/14767058.2018.1468883</a>

Result language

angličtina

Original language name

Congenital heart defects according to the types of the risk factors - a single center experience

Original language description

Objective: The main aim of this study was to compare the prevalence of congenital heart defects (CHDs) between pregnant women with and those without the risk factors. The secondary aim was to determine the influence of the specific risk factors, divided into subgroups, on the development of the CHD. Methods: The presented results were obtained over the course of a 15-year study between years 2002 and 2016. Fetal echocardiography was performed as a planned screening examination during the second trimester of gravidity. A total of 35,831 singleton pregnancies were examined at our center. Risk factors for the development of CHDs were analyzed and divide into the following groups: (i) maternal age >= 35 years; (ii) mother-related risk factors; (iii) pregnancy- and fetus-related risk factors; (iv) pregnancy after in vitro fertilization (IVF); (v) history of CHDs in the first-degree family member; (vi) history of CHDs in the second-degree family member; and (vii) positive genetic family history. Results: The risk factors were identified in 25% (8990/35,831) of pregnancies. In total, CHDs were detected in 1.1% (394/35,831) of fetuses. The prevalence rate of CHDs was higher in the pregnancies with than in those without the risk factors (2.5% [221/8990] versus 0.6% [173/26,841]; p &lt; .0001). The presence of pregnancy- and fetus-related risk factors (odds ratio [OR], 6.5; 95% confidence interval [CI], 4.3-9.7) and pregnancy after IVF (OR, 2.8; 95% CI, 1.5-5.2) were found to be independent risk factors of CHDs. Conclusions: The presence of specific risk factors is related to the increasing prevalence of CHDs. Pregnancy- and fetus-related risk factors and in vitro fertilization were found to be the independent risk factors of CHD.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30214 - Obstetrics and gynaecology

Project

<a href="/en/project/NV17-29111A" target="_blank" >NV17-29111A: A key role of the karyotype in risk stratification for the premature cardiovascular morbidity and mortality in females with Turner syndrome</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Congenital heart defects according to the types of the risk factors - a single center experience

ISSN

1476-7058

e-ISSN

1476-4954

Volume of the periodical

32

Issue of the periodical within the volume

21

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

3606-3611

UT code for WoS article

000478069900017

EID of the result in the Scopus database

2-s2.0-85046669605