Chronobiological study of sex differences in the internal environment in zoletil-anaesthetized rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F20%3AA21028BS" target="_blank" >RIV/61988987:17110/20:A21028BS - isvavai.cz</a>

Result on the web

<a href="https://www.tandfonline.com/doi/pdf/10.1080/09291016.2018.1564577?needAccess=true" target="_blank" >https://www.tandfonline.com/doi/pdf/10.1080/09291016.2018.1564577?needAccess=true</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/09291016.2018.1564577" target="_blank" >10.1080/09291016.2018.1564577</a>

Result language

angličtina

Original language name

Chronobiological study of sex differences in the internal environment in zoletil-anaesthetized rats

Original language description

Although it is generally assumed that females are not significantly more variable than males, there are studies that have demonstrated that differences may be quite large. The aim of the presentin vivostudy was to determine the effect of general anaesthesia on the status of acid-base balance in spontaneously breathing rats of both sexes in dependence on the light-dark cycle. The experiments were performed using zoletil-anaesthetized (30mg/kg [intraperitoneal], Virbac, France) female and male Wistar rats, after a four-week adaptation to a light-dark cycle (12 h:12 h). The animals were divided into four experimental groups according to sex and light period (n = 20). The results demonstrated sex differences in acid-base balance, as well as sex-related differences between the light and dark period in zoletil-anaesthetized rats. Both females and males exhibited the same tendency toward changes in the status of acid-base balance in both light periods. The most unfavourable status in the internal environment was exhibited in males during the light period (the lowest pH, the most pronounced hypoxia and hypercapnia), but with the maintenance of light-dark differences. The light-dark differences in paO(2)and paCO(2)were eliminated in females, not in males. The optimal status of acid-base balance occurred during the dark period in males.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30500 - Other medical sciences

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BIOL RHYTHM RES

ISSN

0929-1016

e-ISSN

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Volume of the periodical

51

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

770-779

UT code for WoS article

000547524200011

EID of the result in the Scopus database

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