Pediatric May-Thurner Syndrome-Systematic review and individual patient data meta-analysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F21%3AA22029R0" target="_blank" >RIV/61988987:17110/21:A22029R0 - isvavai.cz</a>
Alternative codes found
RIV/00843989:_____/21:E0108970
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1111/jth.15284" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1111/jth.15284</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/jth.15284" target="_blank" >10.1111/jth.15284</a>
Alternative languages
Result language
angličtina
Original language name
Pediatric May-Thurner Syndrome-Systematic review and individual patient data meta-analysis
Original language description
Background The outcomes of deep vein thrombosis (DVT) in children with May-Thurner Syndrome (MTS) remain unclear. Objectives This systematic review and patient-level meta-analysis aims to describe the outcomes of children with MTS presenting with DVT. Methods A systematic review of the published literature was performed. Data related to patients <18 years diagnosed with MTS and DVT was extracted. Risk of bias was assessed using the Murad criteria. Outcomes included vessel patency post-treatment, DVT recurrence, and post-thrombotic syndrome (PTS). Predictive and explanatory models were developed for these outcomes. Results In total, 109 cases were identified (age range 4-17 years; 77 females) in 28 studies; 75% of patients had >= 1 additional risk factor for DVT. PTS was seen in 61% of patients, DVT recurrence in 38%, and complete vessel patency post-treatment in 65%. The models developed to predict and explain PTS performed poorly overall. Recurrent thrombosis (adjusted for age and patency) predicted PTS (odds ratio [OR] 3.36, 95% confidence interval [CI] 1.28-8.82). DVT management strategies (adjusted for age and DVT characteristics) predicted vessel patency (OR 2.10, 95% CI 1.43-3.08). Lack of complete vessel patency (adjusted for age and thrombophilia) predicted recurrent DVT (OR 2.70, 95% CI 1.09-6.67). Sensitivity analyses showed the same direction of effects for all outcomes. Conclusions PTS and DVT recurrence occur frequently in pediatric MTS. PTS prediction is complex and it was not possible to identify early predictors to guide clinical practice. Use of imaging-guided therapy and thrombus burden predicted venous patency, and lack of patency predicted DVT recurrence.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Thrombosis and Haemostasis
ISSN
1538-7933
e-ISSN
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Volume of the periodical
19
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
1283-1293
UT code for WoS article
000635769700001
EID of the result in the Scopus database
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