LC3A positive “stone like structures” are differentially associated with survival outcomes and CD68 macrophage infiltration in patients with lung adenocarcinoma and squamous cell carcinoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F21%3AA22029RB" target="_blank" >RIV/61988987:17110/21:A22029RB - isvavai.cz</a>
Alternative codes found
RIV/00843989:_____/21:E0109036
Result on the web
<a href="https://reader.elsevier.com/reader/sd/pii/S0169500221001379?token=923E09410F1D0EB4551E34971EFA65E9E054BEBE11545609D52D89608CE71863B7D6A170308E5DD9AAD2CA0664F928F4&originRegion=eu-west-1&originCreation=20210520073104" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0169500221001379?token=923E09410F1D0EB4551E34971EFA65E9E054BEBE11545609D52D89608CE71863B7D6A170308E5DD9AAD2CA0664F928F4&originRegion=eu-west-1&originCreation=20210520073104</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.lungcan.2021.04.008" target="_blank" >10.1016/j.lungcan.2021.04.008</a>
Alternative languages
Result language
angličtina
Original language name
LC3A positive “stone like structures” are differentially associated with survival outcomes and CD68 macrophage infiltration in patients with lung adenocarcinoma and squamous cell carcinoma
Original language description
Aims: The aim of the study was to analyse the prognostic and predictive value of LC3A positive’ ’Stone Like Structures’’ (SLSs) in a large cohort of patients with non-small cell lung carcinoma (NSCLC) and to check its relationship with tumor infiltrating lymphocytes (TILs) and PD-L1 expression. Methods: Tissue microarrays from 1015 patients diagnosed at the Institute of Pathology and Molecular Pathology, University Hospital Zurich, Switzerland, were stained for LC3A, PD-L1, CD3 and CD68 using automated tissue stainer Ventana Benchmark Ultra (Roche). TILs were assessed in matched haematoxylin and eosin stained slides. Results: LC3A positive SLSs, were significantly associated with worse overall (OS) and disease-free survival (DFS) outcomes in patients with lung adenocarcinoma (LADC) (HR = 2.4, 95 %CI(.994–1.008, p = 0.029) and HR = 3.9, 95 %CI (1.002–1.014), p = 0.002 respectively), whilst it was associated with better OS and DFS in patients with lung squamous cell carcinoma (LUSC), with marginal significance (HR =.99, 95 %CI(.975–1.011),p = 0.042 and HR =.99, 95 %CI (.975–1.008), p = 0.026). Multivariate analysis showed that LC3A SLSs are independent poor prognostic factor only in patients with LADC. In addition, LC3A SLSs, were negatively associated with CD68 count in LADC, whilst there was a positive correlation in LSCC. Conclusions: LC3A SLSs are differentially associated with the survival outcomes and CD68 count in LADC and LSCC. Further studies are justified for the understanding the underlying biological mechanisms of this phenomenon. © 2021
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
LUNG CANCER
ISSN
0169-5002
e-ISSN
1872-8332
Volume of the periodical
156
Issue of the periodical within the volume
červen
Country of publishing house
IE - IRELAND
Number of pages
7
Pages from-to
129-135
UT code for WoS article
000652674900018
EID of the result in the Scopus database
2-s2.0-85105357751